The Chronic Elevated Consumption of Hibiscus sabdariffa Linnaeus Results in Kidney Damage Associated with Excess H2S
Por:
Manzano-Pech L., Soto M.E., Castrejón-Tellez V., Soria-Castro E., Guarner-Lans V., Caballero-Chacón S., Martínez-Memije R., Torres-Narváez J.C., El-Hafidi M., Pérez-Torres I.
Publicada:
1 ene 2026
Resumen:
© 2026 by the authors.Hydrogen sulfide (H2S) is essential for renal function; however, it is toxic at high concentrations. H2S is increased during reductive stress (RS). Increased antioxidant capacity and reduced/oxidized glutathione (GSH/GSSG) characterize a rat model of RS associated with chronic consumption of 6% Hibiscus sabdariffa Linnaeus (HSL). Here, we evaluate if chronic consumption of an infusion of HSL causes kidney damage associated with an increase in H2S. Twenty-one Wistar rats were divided into three groups. Group 1: rats received plain tap water ad libitum (G1); Group 2: rats received an ad libitum infusion of 6% HSL for one month (G2); and Group 3: rats consumed a 6% HSL infusion for one month and were then given natural water for another month (G3). We evaluated renal vasodilatation, cystathionine–ß–synthase (CBS), cystathionine–?–lyase (CSE), 3–mercaptopyruvate-sulfur-transferase (3–MST), ?-glutamylcysteine synthetase (GCLC), Nrf2, total OXPHOS, H2S concentration, GSH/GSSG and oxidized/reduced thiols in the kidney. Renal vasodilatation and total OXPHOS in complex IV and I and oxidized/reduced thiols were decreased (p = 0.01) but H2S, CBS, SCE, GCLC, and NrF2 expression and GSH/GSSG were increased (p = 0.04). The HSL infusion provided cysteine that was metabolized by CBS and CSE, elevating chronic H2S and favoring renal damage.
Filiaciones:
Department of Physiology and Pharmacology UNAM, Facultad de Medicina y Veterinaria y Zootecnia, Av. Universidad 3000, Coyoacán, 04510, Mexico
Research Direction, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Mexico City, Tlalpan, 14080, Mexico
Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City, 14080, Mexico
Department of Cardiovascular Biomedicine, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Mexico City, Tlalpan, 14080, Mexico
Department de Electromechanical Instrumentation, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Mexico City, Tlalpan, 14080, Mexico
Department de Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City, 14080, Mexico
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