Cyclometalated complexes: promising metallodrugs in the battle against cancer
Por:
Amaya-Flórez A., R.-Galindo J., Sanchez-Yocue E., Ruiz-Martinez A., Serrano-García J.S., Romo-Pérez A., Cano-Sanchez P., Reyes-Marquez V., Le Lagadec R., Morales-Morales D.
Publicada:
1 ene 2025
Ahead of Print:
1 jul 2025
Resumen:
This journal is © The Royal Society of Chemistry, 2025Metal-based compounds are excellent alternative drugs for oncological treatment and research. The successful use of cisplatin and its derivatives clearly exemplifies the important role of such compounds in cancer therapy. However, the low selectivity, side effects, and resistance associated with this drug have led to the search for new strategies to overcome these limitations. For this reason, organometallic compounds are gaining significant attention as potential antitumor agents. Compared to platinum-based drugs, these compounds often exhibit greater stability, better lipophilicity, higher selectivity, and reduced resistance in cancer cells. This review aims to illustrate the antitumor properties of cyclometalated compounds containing metals from groups 8, 9, and 10. It also highlights various biochemical studies that attempted to explain how these compounds can enter cells, their different molecular targets, and the types of cell death that they can trigger.
Filiaciones:
Amaya-Flórez A.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad de México, CP 04510, Mexico
R.-Galindo J.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad de México, CP 04510, Mexico
Sanchez-Yocue E.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad de México, CP 04510, Mexico
Ruiz-Martinez A.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad de México, CP 04510, Mexico
Serrano-García J.S.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad de México, CP 04510, Mexico
Romo-Pérez A.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad de México, CP 04510, Mexico
Cano-Sanchez P.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad de México, CP 04510, Mexico
Reyes-Marquez V.:
Departamento de Ciencias Químico-Biológicas, Universidad de Sonora, Luis Encinas y Rosales S/N, Hermosillo 83000, Sonora, Mexico
Le Lagadec R.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad de México, CP 04510, Mexico
Morales-Morales D.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad de México, CP 04510, Mexico
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