Circulation of RSV Subtypes A and B Among Mexican Children During the 2021-2022 and 2022-2023 Seasons
Por:
Zárate, S, Taboada, B, Torres-Rivera, K, Bautista-Carbajal, P, Garcia-León, ML, Tabla-Orozco, V, Juárez-Tobías, MS, Noyola, DE, Martínez-Arce, PA, Espinosa-Sotero, MD, Martínez-Aguilar, G, Rojas-Larios, F, Sanchez-Flores, A, Arias, CF, Wong-Chew, RM
Publicada:
2 oct 2025
Resumen:
Respiratory syncytial virus (RSV) remains a leading cause of pneumonia in young children in Mexico and worldwide. To investigate RSV dynamics in Mexico, we conducted a multicenter study from August 2021 to July 2023 in six hospitals across five States, analyzing respiratory samples from children under five years with pneumonia. Multiplex RT-PCR identified 203 RSV-positive cases, of which 123 were RSV-B and 80 RSV-A. Interestingly, 77% of the collected samples showed evidence of coinfection with other respiratory pathogens, with rhinovirus, Haemophilus influenzae, and Streptococcus pneumoniae being the most common. Also, RSV-B dominated in 2021-2022, whereas RSV-A prevailed in 2022-2023, mirroring trends observed in the United States. Sequences of the genes encoding G and F proteins showed that RSV-A lineages were more diverse, with A.D.1, A.D.1.8, and A.D.5.2 being frequently detected. In contrast, nearly all RSV-B sequences belonged to lineage B.D.E.1. Finally, ancestral state inference suggests repeated introductions from the USA and other North American countries, with limited evidence of sustained local circulation. These findings show different trends in RSV circulation between two consecutive seasons and the importance of genomic surveillance to monitor RSV diversity, evaluate vaccine impact, and inform public health strategies in Mexico's evolving post-pandemic respiratory virus landscape.
Filiaciones:
Zárate, S:
Univ Autonoma Ciudad Mexico, Posgrad Ciencias Genomicas, Mexico City 03100, Mexico
Taboada, B:
Univ Nacl Autonoma Mexico, Dept Genet Desarrollo & Fisiol Mol, Inst Biotecnol, Cuernavaca 62210, Mexico
Torres-Rivera, K:
Univ Autonoma Ciudad Mexico, Posgrad Ciencias Genomicas, Mexico City 03100, Mexico
Bautista-Carbajal, P:
Univ Nacl Autonoma Mexico, Fac Med, Res Div, Infect Dis Res Lab, Mexico City 04510, Mexico
Garcia-León, ML:
Univ Nacl Autonoma Mexico, Fac Med, Res Div, Infect Dis Res Lab, Mexico City 04510, Mexico
Tabla-Orozco, V:
Hosp Pediatr Coyoacan, Mexico City 04100, Mexico
Juárez-Tobías, MS:
Hosp Cent Dr Ignacio Morones Prieto, San Luis Potosi 78210, Mexico
Noyola, DE:
Univ Autonoma San Luis Potosi, Ctr Invest Ciencias Salud & Biomed, San Luis Potosi 78210, Mexico
Martínez-Arce, PA:
Antiguo Hosp Civil Guadalajara Fray Antonio Alcald, Guadalajara 44280, Mexico
Espinosa-Sotero, MD:
Hosp Gen Mexico Dr Eduardo Liceaga, Mexico City 06720, Mexico
Martínez-Aguilar, G:
Hosp Municipal Nino Durango, Durango 34167, Mexico
Univ Juarez Estado Durango, Fac Med & Nutr, Durango 34000, Mexico
Rojas-Larios, F:
Hosp Reg IMSS Bienestar Colima, Colima 28085, Mexico
Sanchez-Flores, A:
Univ Nacl Autonoma Mexico, Unidad Univ Secuenciac Mas & Bioinformat, Inst Biotecnol, Cuernavaca 62210, Mexico
Arias, CF:
Univ Nacl Autonoma Mexico, Dept Genet Desarrollo & Fisiol Mol, Inst Biotecnol, Cuernavaca 62210, Mexico
Wong-Chew, RM:
Univ Nacl Autonoma Mexico, Fac Med, Res Div, Infect Dis Res Lab, Mexico City 04510, Mexico
Green Submitted, gold, All Open Access; Gold Open Access; Green Open Access
|