Histopathology and blood biochemistry in sheep treated with an experimental intramuscular fasciolicide
Por:
Arias-García, R, Ibarra-Velarde, F, Vera-Montenegro, Y, Flores-Ramos, M, Hernández-Campos, A, Leyva-Gómez, G
Publicada:
1 ene 2025
Resumen:
The aim of present study was to determine whether intramuscular administration of injectable fasciolicide prodrug, fosfatriclaben, in a single dose at 6 mg/kg in mixed breed sheep, produces adverse reactions reflected in blood biochemical and histopathological profiles, particularly in tissues involved in drug metabolism. For this purpose, two sheep groups were formed. Group 1 (G1) of 15 sheep was treated, Group 2 (G2) of 5 sheep served as control. On days 0, 7, 14, 28, and 35 post-treatment, liver, kidney, and injection site samples were taken for histopathology, as well as blood samples for biochemical analysis. The results did not provide important histopathological changes or significant differences in blood biochemical (P < 0.05); analytes values remained within the reference range. It is estimated that the trial prodrug could have similar safety characteristics to its precursor, triclabendazole. © 2025, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico. All rights reserved.
Filiaciones:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Parasitol, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Escuela Nacl Estudios Super, Unidad Merida, Yucatan, Mexico
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City, Mexico
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