Genetics of metabolic obesity phenotypes
Por:
Olivares-Arévalo, M, Villamil-Ramírez, H, López-Contreras, B, León-Mimila, P, Villarreal-Molina, T, Canizales-Quinteros, S
Publicada:
1 ene 2025
Resumen:
Although obesity is an important risk factor for cardiometabolic diseases, not every individual with obesity shows metabolic complications, this phenotype is called metabolically healthy obesity (MHO). Several studies suggest that the distribution of body fat and its accumulation in ectopic depots, rather than overall adiposity, are important factors in defining the metabolic health of individuals with obesity. The identification of genes involved in fat accumulation, particularly in the expansion of subcutaneous adipose tissue, has contributed to better understanding the physiological mechanisms related to metabolic health. Notably, some Latin American populations have an increased susceptibility to the development of metabolic complications. In this review, we discuss the differences in the prevalence of MHO among populations, including Latin Americans, as well as some of the main genetic findings related to healthy and unhealthy metabolic phenotypes of obesity.
Filiaciones:
Olivares-Arévalo, M:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Unidad Genom Poblac Aplicada Salud, Mexico City, Mexico
Inst Nacl Med Genom, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Programa Maestria & Doctorado Ciencias Bioquim, Mexico City, Mexico
Villamil-Ramírez, H:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Unidad Genom Poblac Aplicada Salud, Mexico City, Mexico
Inst Nacl Med Genom, Mexico City, Mexico
López-Contreras, B:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Unidad Genom Poblac Aplicada Salud, Mexico City, Mexico
Inst Nacl Med Genom, Mexico City, Mexico
León-Mimila, P:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Unidad Genom Poblac Aplicada Salud, Mexico City, Mexico
Inst Nacl Med Genom, Mexico City, Mexico
Villarreal-Molina, T:
Inst Nacl Med Genom, Lab Genom Enfermedades Cardiovasc, Mexico City, Mexico
Canizales-Quinteros, S:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Unidad Genom Poblac Aplicada Salud, Mexico City, Mexico
Inst Nacl Med Genom, Mexico City, Mexico
gold, All Open Access; Gold Open Access
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