The ongoing antibiotic resistance and carbapenemase encoding genotypes surveillance. The first quarter report of the INVIFAR network for 2024.
Por:
Colín-Castro C.A., López-Jácome L.E., Rodríguez-García M.J., Garibaldi-Rojas M., Rojas-Larios F., Vázquez-Larios M.D.R., Quintana-Ponce S., Franco-Cendejas R., Gómez-Quiróz A., Rodríguez-Zulueta P., Rosado-Espinosa T., Quintanilla-Cazares L.J., Velázquez-Acosta C., Sandoval-Villaseñor P.H., Mena-Ramírez J.P., Choy-Chang E.V., González-Lara M.F., Martínez-Guerra B.A., Bolado-Martínez E., Aviles-Benítez L.K., Feliciano-Guzmán J.M., Couoh-May C.A., Pérez-Vicelis T., Silva-Gamiño A.R., Rivera-Garay L.R., Navarro-Vargas N.V., Gutiérrez-Brito M., Adame-Álvarez C., Suárez-Moreno S.M., Pérez-Vega B.A., López-Moreno L.I., Jacobo-Baca G., Galindo-Méndez M., Ballesteros-Silva M.B., Vázquez-Narvaez E.G., Barlandas-Rendón N.R.E., Rodríguez-Balderas D.E., de Dios Castañeda-Duarte J., Padilla-Ibarra C., Peralta-Peñúñuri V.H., López-Vázquez A.D., Santiago-Calderón M.A., Valtierra Á.C., González-Melgoza P.F., Medina-Navarro L.G., Mireles-Dávalos C.D., De-La-Cruz-Hernández I., Huirache-Villalobos G.S., Aguilar-Trejo E.M., López-Álvarez M.D.R., Garza-González E.
Publicada:
1 ene 2025
Resumen:
Introduction Antimicrobial resistance surveillance plays an important role in generating information about the prevalence of resistant microorganisms. In this study, we summarize a surveillance of antimicrobial resistance and carbapenemase-encoding genes for selected pathogens in Mexican healthcare centers. Methods Databases of identification and susceptibility results collected from January 1 to March 31, 2024, from forty-one centers were gathered and analyzed using the WHONET software. Some relevant gram-negatives and gram-positives, which were isolated from relevant clinical specimens were included. Isolates were stratified by patient´s age, clinical specimens, and site of attention, and were classified as multidrug-resistant (MDR). Clinical isolates were collected from January 1 to June 30 and were genotyped for carbapenemase-encoding genes by a polymerase chain reaction test. Results In total, 8 708 strains were included. Escherichia coli had a higher resistance to carbapenems (p < 0.05) in the 0–17 years group and Klebsiella pneumoniae (p = 0.017), Pseudomonas aeruginosa, and Acinetobacter baumannii (p < 0.05) in the 18–59 years group. P. aeruginosa had higher resistance to ceftazidime-avibactam, ceftolozane-tazobactam, cefepime, and imipenem (p < 0.05) in the 18–59 years group. K. pneumoniae had the highest resistance to carbapenems (p < 0.05) and cefepime (p < 0.001) in clinical isolates recovered from blood. For P. aeruginosa, the highest resistance to cefepime (p = 0.012) and ceftazidime (p < 0.018) was seen in isolates from urine. For Staphylococcus aureus, a higher resistance was observed for cefoxitin in lower respiratory tract specimens (p < 0.05). E. coli had the highest resistance to carbapenems (p < 0.01), and P. aeruginosa for ceftazidime (p = 0.005), cefepime (p = 0.003), piperacillin-tazobactam (p = <0.01), IPM (p = 0.006), and meropenem (p = <0.01) in clinical isolates recovered from patients in the intensive care unit (ICU). For K. pneumoniae, the highest resistance to ertapenem was observed in clinical isolates from the ICU area (p < 0.035). Finally, 67.9% of A. baumannii and 53.8% of E. coli strains were Multidrug-resistant. Candida albicans isolated from blood had susceptibility to caspofungin 100% and 90.2% for voriconazole. Regarding E. coli non-susceptible to meropenem, 16 (59.2%) were carriers of blaNDM, and the blaKPC gene was detected in 2 (40%) strains of K. pneumoniae. In conclusion, carbapenem resistance was higher for E. coli in the 0–17 years group and for K. pneumoniae, P. aeruginosa, and A. baumannii in the 18–59 years group. K. pneumoniae has the highest resistance to carbapenems in blood isolates and the ICU area. E. coli and P. aeruginosa had the highest carbapenem resistance in the intensive care unit. A high multidrug resistance was observed for A. baumannii and E. coli strains. A high susceptibility to caspofungin and voriconazole was observed for Candida albicans collected from blood. © 2025 Colín-Castro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Filiaciones:
Colín-Castro C.A.:
Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City, Mexico
López-Jácome L.E.:
Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City, Mexico
Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, México City, Mexico
Rodríguez-García M.J.:
Universidad Autónoma de Guerrero, Guerrero, Chilpancingo, Mexico
Garibaldi-Rojas M.:
Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Nuevo León, Monterrey, Mexico
Rojas-Larios F.:
Universidad de Colima, Colima, Colima, Mexico
Hospital Regional Universitario de los Servicios de Salud del Estado de Colima, Colima, Colima, Mexico
Vázquez-Larios M.D.R.:
Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Quintana-Ponce S.:
Universidad Autónoma de Guerrero, Guerrero, Chilpancingo, Mexico
Franco-Cendejas R.:
Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City, Mexico
Gómez-Quiróz A.:
Laboratorio de Microbiología, Hospital Civil de Guadalajara, Jalisco, Guadalajara, Mexico
Rodríguez-Zulueta P.:
Hospital General Dr. Manuel Gea González, Mexico City, Mexico
Rosado-Espinosa T.:
Hospital General Dr. Manuel Gea González, Mexico City, Mexico
Quintanilla-Cazares L.J.:
Hospital Ángeles Valle Oriente. Monterrey, Nuevo León, Mexico
Velázquez-Acosta C.:
Instituto Nacional de Cancerología, Mexico City, Mexico
Sandoval-Villaseñor P.H.:
Universidad de Colima, Colima, Colima, Mexico
Hospital Regional Universitario de los Servicios de Salud del Estado de Colima, Colima, Colima, Mexico
Mena-Ramírez J.P.:
Hospital General de Zona No. 21, IMSS, Jalisco, Tepatitlan de Morelos, Mexico
Centro Universitario de los Altos (CUALTOS), Universidad de Guadalajara, Jalisco, Tepatitlán de Morelos, Mexico
Choy-Chang E.V.:
Hospital General de Zona No.1, Nueva Frontera. IMSS, Chiapas, Tapachula, Mexico
González-Lara M.F.:
Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Martínez-Guerra B.A.:
Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Bolado-Martínez E.:
Universidad de Sonora, Sonora, Hermosillo, Mexico
Aviles-Benítez L.K.:
Hospital Infantil de Morelia, Michoacán, Morelia, Mexico
Feliciano-Guzmán J.M.:
Hospital de Especialidades Pediátricas, Chiapas, Tuxtla Gutiérrez, Mexico
Couoh-May C.A.:
Hospital General Dr. Agustín O´Horan, Yucatán, Mérida, Mexico
Pérez-Vicelis T.:
Hospital de Alta Especialidad Bicentenario de la Independencia. ISSSTE, Estado de México, Tultitlán, Mexico
Silva-Gamiño A.R.:
Hospital Ángeles Morelia, Michoacán, Morelia, Mexico
Rivera-Garay L.R.:
Hospital Regional de Alta Especialidad del Bajío, Guanajuato, León, Mexico
Navarro-Vargas N.V.:
Hospital General Presidente Lázaro Cárdenas del Río. ISSSTE, Chihuahua, Chihuahua, Mexico
Gutiérrez-Brito M.:
Hospital del Niño Poblano, Puebla, San Andrés Cholula, Mexico
Adame-Álvarez C.:
Centenario Hospital Miguel Hidalgo, Aguascalientes, Aguascalientes, Mexico
Suárez-Moreno S.M.:
Laboratorio Dipromi, Michoacán, Morelia, Mexico
Pérez-Vega B.A.:
Hospital Ángeles Chihuahua, Chihuahua, Chihuahua, Mexico
López-Moreno L.I.:
Hospital Galenia, Quintana Roo, Cancún, Mexico
Jacobo-Baca G.:
Centro Universitario de Salud, Universidad Autónoma de Nuevo León, Nuevo León, Monterrey, Mexico
Galindo-Méndez M.:
Laboratorio Galindo, Oaxaca, Oaxaca, Mexico
Ballesteros-Silva M.B.:
Centro de Diagnóstico Microbiológico, Michoacán, Morelia, Mexico
Vázquez-Narvaez E.G.:
Hospital General Dr. Miguel Silva, Michoacán, Morelia, Mexico
Barlandas-Rendón N.R.E.:
Laboratorio BIOCLIN, Guerrero, Chilpancingo, Mexico
Rodríguez-Balderas D.E.:
Hospital del Niño Dr. Federico Gómez Santos, Coahuila, Saltillo, Mexico
de Dios Castañeda-Duarte J.:
Centro Médico Dr. Ignacio Chávez, Sonora, Hermosillo, Mexico
Padilla-Ibarra C.:
Hospital General del Estado de Sonora, Sonora, Hermosillo, Mexico
Peralta-Peñúñuri V.H.:
Hospital General Dr. Fernando Ocaranza, Sonora, Hermosillo, Mexico
López-Vázquez A.D.:
Centro Integral de Atención a la Salud Sur. ISSSTE, Sonora, Hermosillo, Mexico
Santiago-Calderón M.A.:
Hospital General de Zona 1, IMSS, Oaxaca, Oaxaca, Mexico
Valtierra Á.C.:
Hospital General de León, Guanajuato, León, Mexico
González-Melgoza P.F.:
Laboratorio de análisis clínicos y microbiológicos Futura Médica, Michoacán, Morelia, Mexico
Medina-Navarro L.G.:
Hospital General de Silao, Guanajuato, Silao, Mexico
Mireles-Dávalos C.D.:
Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
De-La-Cruz-Hernández I.:
Hospital General de Zona 46, IMSS, Tabasco, Villahermosa, Mexico
Huirache-Villalobos G.S.:
Laboratorio Clínico y Bacteriológico La Barca, Jalisco, Mexico
Aguilar-Trejo E.M.:
Laboratorio Biodiagnostics, Tlaxcala, Apizaco, Mexico
López-Álvarez M.D.R.:
Hospital Regional General Ignacio Zaragoza, Mexico City, Mexico
Garza-González E.:
Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Nuevo León, Monterrey, Mexico
gold, All Open Access; Gold Open Access
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