miRNAs-Set of Plasmatic Extracellular Vesicles as Novel Biomarkers for Hepatocellular Carcinoma Diagnosis Across Tumor Stage and Etiologies
Por:
Molina-Pelayo F.A., Zarate-Lopez D., García-Carrillo R., Rodríguez-Beas C., Íñiguez-Palomares R., Rodríguez-Mejía J.L., Soto-Guzmán A., Velasco-Loyden G., Sierra-Martínez M., Virgen-Ortiz A., Sánchez-Pastor E., Magaña-Vergara N.E., Baltiérrez-Hoyos R., Alamilla J., Chagoya de Sánchez V., Dagnino-Acosta A., Chávez E., Castro-Sánchez L.
Publicada:
1 ene 2025
Resumen:
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, often diagnosed at advanced stages due to insufficient early screening and monitoring. MicroRNAs (miRNAs) are key regulators of gene expression and potential biomarkers for cancer diagnosis. This study investigated the diagnostic potential of miRNAs in Extracellular Vesicles (EVs) from HCC. miRNA expression in EVs was analyzed using HCC cell lines, circulating EVs from a Diethylnitrosamine (DEN)-induced liver tumor rat model, and plasma samples from HCC patients. Receiver Operating Characteristics (ROCs) were applied to evaluate the diagnostic accuracy of circulating EV miRNAs in patients. Five miRNAs (miR-183-5p, miR-19a-3p, miR-148b-3p, miR-34a-5p, and miR-215-5p) were consistently up-regulated in EVs across in vitro and in vivo HCC models. These miRNAs showed statistically significant differences in HCC patients stratified by TNM staging and Edmondson–Steiner grading compared to healthy controls. They also differentiated HCC patients with various etiologies from the control group and distinguished HCC patients, with or without liver cirrhosis, from cirrhotic and healthy individuals. Individually and as a panel, they demonstrated high sensitivity, specificity, and accuracy in identifying HCC patients. Their consistent upregulation across models and clinical samples highlights their robustness as biomarkers for HCC diagnosis, offering the potential for early disease management and prognosis. © 2025 by the authors.
Filiaciones:
Molina-Pelayo F.A.:
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, 28045, Mexico
Zarate-Lopez D.:
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, 28045, Mexico
García-Carrillo R.:
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, 28045, Mexico
Rodríguez-Beas C.:
Departamento de Física, Universidad de Sonora, Sonora, Hermosillo, 83000, Mexico
Íñiguez-Palomares R.:
Departamento de Física, Universidad de Sonora, Sonora, Hermosillo, 83000, Mexico
Rodríguez-Mejía J.L.:
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, 28045, Mexico
Soto-Guzmán A.:
Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, Sonora, Hermosillo, 83000, Mexico
Velasco-Loyden G.:
Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico
Sierra-Martínez M.:
Unidad de investigación en Salud, Hospital Regional de Alta Especialidad de Ixtapaluca, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-BIENESTAR), Ciudad de México, 01020, Mexico
Virgen-Ortiz A.:
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, 28045, Mexico
Sánchez-Pastor E.:
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, 28045, Mexico
Magaña-Vergara N.E.:
Facultad de Ciencias Químicas, Universidad de Colima, Colima, Coquimatlán, 28400, Mexico
SECIHTI—Universidad de, Colima, Colima, Colima, 28045, Mexico
Baltiérrez-Hoyos R.:
SECIHTI—Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca, Oaxaca, 68120, Mexico
Alamilla J.:
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, 28045, Mexico
SECIHTI—Universidad de, Colima, Colima, Colima, 28045, Mexico
Chagoya de Sánchez V.:
Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico
Dagnino-Acosta A.:
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, 28045, Mexico
SECIHTI—Universidad de, Colima, Colima, Colima, 28045, Mexico
Chávez E.:
Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico
Castro-Sánchez L.:
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, 28045, Mexico
SECIHTI—Universidad de, Colima, Colima, Colima, 28045, Mexico
gold, All Open Access; Gold Open Access
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