Blue benzoquinone from scorpion venom shows bactericidal activity against drug-resistant strains of the priority pathogen Acinetobacter baumannii
Por:
Gallegos-Monterrosa, R, Cid-Uribe, JI, Delgado-Prudencio, G, Pérez-Morales, D, Banda, MM, Téllez-Galván, A, Carcamo-Noriega, EN, Garza-Ramos, U, Zare, RN, Possani, LD, Bustamante, VH
Publicada:
1 mar 2025
Ahead of Print:
1 feb 2025
Resumen:
Antibiotic-resistant bacteria pose a significant global health threat, particularly pathogens resistant to last-resort antibiotics, such as those listed as priority pathogens by the World Health Organization. Addressing this challenge requires the development of novel antimicrobial agents. Previously, we identified a blue 1,4-benzoquinone isolated from the venom of the Mexican scorpion Diplocentrus melici as a potent antimicrobial compound effective against Staphylococcus aureus and Mycobacterium tuberculosis. Moreover, we devised a cost-effective synthetic route for its production. In this study, we demonstrate that the blue benzoquinone exhibits antibacterial activity against additional pathogens, including the priority pathogen Acinetobacter baumannii. Notably, the compound effectively killed clinical strains of A. baumannii resistant to multiple antibiotics, including carbapenem and colistin. Furthermore, A. baumannii did not develop resistance to the benzoquinone even after multiple growth cycles under sub-inhibitory concentrations, unlike the tested antibiotics. These findings underscore the potential of this blue benzoquinone as a lead compound for the development of a new class of antibiotics targeting multidrug-resistant bacteria.
Filiaciones:
Univ Nacl Autonoma Mexico, Dept Microbiol Mol, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
Univ Nacl Autonoma Mexico, Dept Med Mol & Bioproc, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
Univ Nacl Autonoma Mexico, Ctr Ciencias Genom, Programa Biol Sistemas, Cuernavaca 62210, Morelos, Mexico
Univ Nacl Autonoma Mexico, Programa Ingn Genom, Ctr Ciencias Genom, Cuernavaca 62210, Morelos, Mexico
Inst Nacl Salud Publ, Lab Resistencia Bacteriana, Ctr Invest Enfermedades Infecciosas, Cuernavaca 62210, Morelos, Mexico
Stanford Univ, Dept Chem, Stanford, CA 94305 USA
hybrid, All Open Access; Hybrid Gold Open Access
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