Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method


Por: Mitnick C.D., White R.A., Lu C., Rodriguez C.A., Bayona J., Becerra M.C., Burgos M., Centis R., Cohen T., Cox H., D'Ambrosio L., Danilovitz M., Falzon D., Gelmanova I.Y., Gler M.T., Grinsdale J.A., Holtz T.H., Keshavjee S., Leimane V., Menzies D., Migliori G.B., Milstein M.B., Mishustin S.P., Pagano M., Quelapio M.I., Shean K., Shin S.S., Tolman A.W., Van Der Walt M.L., Van Deun A., Viiklepp P., Ahuja S.D., Andreev Y.G., Ashkin D., Avendano M., Banerjee R., Bauer M., Benedetti A., Brand J., Chan E.D., Chiang C.Y., DeRiemer K., Dung N.H., Enarson D., Flanagan K., Flood J., García-García L., Gandhi N., Granich R.M., Hollm-Delgado M.G., Iseman M.D., Jarlsberg L.G., Kim H.R., Koh W.-J., Lancaster J., Lange C., De Lange W.C.M., Leung C.C., Li J., Maug A.K.J., Narita M., Odendaal R., O'Riordan P., Pai M., Palmero D., Seung-Kyu, Pasvol G., Peña J., Pérez-Guzmán C., Ponce-de-Leon A., Riekstina V., Robert J., Royce S., Schaaf H.S., Seung K.J., Shah L., Shim T.S., Shiraishi Y., Sifuentes-Osornio J., Strand M.J., Shaheed P.T., Tupasi T.E., Van Altena R., Van Der Werf T.S., Vargas M.H., Westenhouse J., Yew W.W., Yim J.-J.

Publicada: 1 ene 2016
Resumen:
Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of monitoring strategies on timing of failure detection. We identified studies reporting microbiological response to MDR-TB treatment and solicited individual patient data from authors. Frailty survival models were used to estimate pooled relative risk of failure detection in the last 12 months of treatment; hazard of failure using monthly culture was the reference. Data were obtained for 5410 patients across 12 observational studies. During the last 12 months of treatment, failure detection occurred in a median of 3 months by monthly culture; failure detection was delayed by 2, 7, and 9 months relying on bimonthly culture, monthly smear and bimonthly smear, respectively. Risk (95% CI) of failure detection delay resulting from monthly smear relative to culture is 0.38 (0.34-0.42) for all patients and 0.33 (0.25-0.42) for HIV-co-infected patients. Failure detection is delayed by reducing the sensitivity and frequency of the monitoring method. Monthly monitoring of sputum cultures from patients receiving MDR-TB treatment is recommended. Expanded laboratory capacity is needed for high-quality culture, and for smear microscopy and rapid molecular tests. copyright ©ERS 2016.

Filiaciones:
Mitnick C.D.:
 Dept of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, 02115, MA, United States

 Partners in Health, Boston, MA, United States

White R.A.:
 Dept of Infectious Disease Epidemiology, Norwegian Institute of Public Health, Oslo, Norway

 Dept of Health Statistics, Norwegian Institute of Public Health, Oslo, Norway

Lu C.:
 Dept of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, 02115, MA, United States

 Brigham and Women's Hospital, Division of Global Health Equity, Boston, MA, United States

Rodriguez C.A.:
 Dept of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, 02115, MA, United States

Bayona J.:
 Socios en Salud Sucursal, Lima, Peru

Becerra M.C.:
 Dept of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, 02115, MA, United States

 Partners in Health, Boston, MA, United States

 Brigham and Women's Hospital, Division of Global Health Equity, Boston, MA, United States

Burgos M.:
 Dept of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, United States

Centis R.:
 WHO Collaborating Centre for TB and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute, Tradate, Italy

Cohen T.:
 Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States

Cox H.:
 Médecins Sans Frontières, Cape Town, South Africa

D'Ambrosio L.:
 WHO Collaborating Centre for TB and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute, Tradate, Italy

 Public Health Consulting Group, Lugano, Switzerland

Danilovitz M.:
 Tartu University Hospital, Lung Clinic, Tartu, Estonia

Falzon D.:
 Global TB Programme, World Health Organization., Geneva, Switzerland

Gelmanova I.Y.:
 Partners in Health Russia, Moscow, Russian Federation

Gler M.T.:
 Makati Medical Center, Manila, Philippines

Grinsdale J.A.:
 Tuberculosis Control, San Francisco Department of Public Health, San Francisco, CA, United States

Holtz T.H.:
 US Centers for Disease Control and Prevention, Atlanta, GA, United States

Keshavjee S.:
 Dept of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, 02115, MA, United States

 Partners in Health, Boston, MA, United States

 Brigham and Women's Hospital, Division of Global Health Equity, Boston, MA, United States

Leimane V.:
 State Agency for Tuberculosis and Lung Diseases (TPSVA), Riga, Latvia

Menzies D.:
 Montreal Chest Institute, McGill University, Montreal, QC, Canada

Migliori G.B.:
 WHO Collaborating Centre for TB and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute, Tradate, Italy

Milstein M.B.:
 Dept of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, 02115, MA, United States

 Bouvé College of Health Sciences, Northeastern University, Boston, MA, United States

Mishustin S.P.:
 Tomsk TB and Pulmonary Medical Center, Tomsk Oblast, Russian Federation

Pagano M.:
 Dept of Biostatistics, Harvard School of Public Health, Boston, MA, United States

Quelapio M.I.:
 Tropical Disease Foundation, Philippine Institute of Tuberculosis, Makati City, Philippines

Shean K.:
 Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Dept of Medicine, University of Cape Town, Cape Town, South Africa

Shin S.S.:
 Dept of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, 02115, MA, United States

 Partners in Health, Boston, MA, United States

 Brigham and Women's Hospital, Division of Global Health Equity, Boston, MA, United States

 Socios en Salud Sucursal, Lima, Peru

Tolman A.W.:
 Dept of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, 02115, MA, United States

Van Der Walt M.L.:
 South African Medical Research Council, Tuberculosis Research Platform, Pretoria, South Africa

Van Deun A.:
 Institute of Tropical Medicine, Antwerp, Belgium

Viiklepp P.:
 National Institute for Heath Development, Tallinn, Estonia

Ahuja S.D.:
 Bureau of Tuberculosis, New York, NY, United States

Andreev Y.G.:
 Tomsk Penitentiary Services, Ministry of Justice, Tomsk, Russian Federation

Ashkin D.:
 A.G. Holley Hospital, Lantan, FL, United States

Avendano M.:
 University of Toronto, Toronto, Canada

Banerjee R.:
 Mayo Clinic, Rochester, MN, United States

Bauer M.:
 Montreal Chest Institute, McGill University, Montreal, Canada

Benedetti A.:
 Montreal Chest Institute, McGill University, Montreal, Canada

Brand J.:
 Medical Research Council, Pretoria, South Africa

Chan E.D.:
 Veterans Affairs Eastern Colorado Health Care System, Denver, CO, United States

Chiang C.Y.:
 UC Davis School of Medicine, Davis, CA, United States

DeRiemer K.:
 UC Davis School of Medicine, Davis, CA, United States

Dung N.H.:
 National TB Control Program, Hanoi, Viet Nam

Enarson D.:
 International Union Against Tuberculosis and Lung Disease, Paris, France

Flanagan K.:
 MRC Laboratories, Banjul, Gambia

Flood J.:
 California Department of Public Health, Sacramento, CA, United States

García-García L.:
 Instituto Nacional de Salud Pública, Mexico

Gandhi N.:
 US Centers for Disease Control and Prevention, Atlanta, GA, United States

Granich R.M.:
 US Centers for Disease Control and Prevention, Atlanta, GA, United States

Hollm-Delgado M.G.:
 Montreal Chest Institute, McGill University, Montreal, Canada

Iseman M.D.:
 University of California, San Francisco, CA, United States

Jarlsberg L.G.:
 University of California, San Francisco, CA, United States

Kim H.R.:
 Korea Cancer Center Hospital, Seoul, South Korea

Koh W.-J.:
 Samsung Medical Center, Seoul, South Korea

Lancaster J.:
 Medical Research Council, Pretoria, South Africa

Lange C.:
 Medical Clinic, Tuberculosis Center Borstel, Borstel, Germany

De Lange W.C.M.:
 University Medical Center Gronigen, Gronigen, Netherlands

Leung C.C.:
 Tuberculosis and Chest Services, Hong Kong

Li J.:
 New York City Health and Mental Hygiene, New York, NY, United States

Maug A.K.J.:
 Damien Foundation, Dhaka, Bangladesh

Narita M.:
 University of Washington, Seattle, WA, United States

Odendaal R.:
 Medical Research Council, Pretoria, South Africa

O'Riordan P.:
 City Road Medical Centre, London, United Kingdom

Pai M.:
 Montreal Chest Institute, McGill University, Montreal, Canada

Palmero D.:
 Hospital F.J. Muñiz, Buenos Aires, Argentina

Seung-Kyu:
 Park TB Center, Seoul, South Korea

Pasvol G.:
 Imperial College London, London, United Kingdom

Peña J.:
 Universidad Autonoma Madrid, Madrid, Spain

Pérez-Guzmán C.:
 Instituto de Salud Del Estado de Aguascalientes, Aguascalientes, Mexico

Ponce-de-Leon A.:
 Instituto Nacional de Ciencias Médicas y de Nutrición Salvador Zubirán, Mexico

Riekstina V.:
 Clinic of Tuberculosis and Lung Diseases, Riga, Latvia

Robert J.:
 Bactériologie-Hygiène-UPMC, Paris, France

Royce S.:
 University of California, San Francisco, CA, United States

Schaaf H.S.:
 Stellenbosch University, Stellenbosch, South Africa

Seung K.J.:
 Brigham and Women's Hospital, Boston, MA, United States

Shah L.:
 Montreal Chest Institute, McGill University, Montreal, Canada

Shim T.S.:
 University of Ulsan College of Medicine, Seoul, South Korea

Shiraishi Y.:
 Fukujuji Hospital, Tokyo, Japan

Sifuentes-Osornio J.:
 Instituto Nacional de Ciencias Médicas y de Nutrición Salvador Zubirán, Mexico

Strand M.J.:
 National Jewish Health, Denver, Co, United States

 University of California, San Francisco, CA, United States

Shaheed P.T.:
 Beheshti Medical University, Tehran, Iran

Tupasi T.E.:
 Tropical Disease Foundation, Makati City, Philippines

Van Altena R.:
 University Medical Center Gronigen, Gronigen, Netherlands

Van Der Werf T.S.:
 University Medical Center Gronigen, Gronigen, Netherlands

Vargas M.H.:
 Instituto Nacional de Enfermedades Respiratorias, Mexico

Westenhouse J.:
 Center for Infectious Diseases-California Department of Public Health, Sacramento, CA, United States

Yew W.W.:
 Grantham Hospital, Hong Kong, Hong Kong

Yim J.-J.:
 Seoul National University College of Medicine, Seoul, South Korea
ISSN: 09031936
Editorial
EUROPEAN RESPIRATORY SOC JOURNALS LTD, 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 48 Número: 4
Páginas: 1160-1170
WOS Id: 000388307500023
ID de PubMed: 27587552
imagen All Open Access; Green Open Access; Hybrid Gold Open Access

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