Understanding Sociodemographic Factors among Hispanics Through a Population-Based Study on Testicular Cancer in Mexico
Por:
Rios-Rodríguez, JA, Montalvo-Casimiro, M, Alvarez-López, DI, Reynoso-Noverón, N, Cuevas-Estrada, B, Mendoza-Pérez, J, Jiménez-Ríos, MA, Wegman-Ostrosky, T, Salcedo-Tello, P, Scavuzzo, A, Castro-Hernández, C, Herrera, LA, González-Barrios, R
Publicada:
1 feb 2025
Ahead of Print:
1 nov 2023
Resumen:
Testicular cancer (TCa) is a rare malignancy affecting young men worldwide. Sociodemographic factors, especially socioeconomic level (SEL) and healthcare access, seem to impact TCa incidence and outcomes, particularly among Hispanic populations. However, limited research has explored these variables in Hispanic groups. This study aimed to investigate sociodemographic and clinical factors in Mexico and their role in health disparities among Hispanic TCa patients. We retrospectively analyzed 244 Mexican TCa cases between 2007 and 2020 of a representative cohort with diverse social backgrounds from a national reference cancer center. Logistic regression identified risk factors for fatality: non-seminoma histology, advanced stage, and lower education levels. Age showed a significant trend as a risk factor. Patient delay and healthcare distance lacked significant associations. Inadequate treatment response and chemotherapy resistance were more likely in advanced stages, while higher education positively impacted treatment response. Cox regression highlighted non-seminoma histology, below-median SEL, higher education, and advanced-stage survival rates. Survival disparities emerged based on tumor histology and patient SEL. This research underscores the importance of comprehensive approaches that integrate sociodemographic, biological, and environmental factors to address health disparities improving outcomes through personalized interventions in Hispanic individuals with TCa.
Filiaciones:
Rios-Rodríguez, JA:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 14080, DF, Mexico
Tecnol Monterrey, Escuela Med & Ciencias Salud, Monterrey 64710, Mexico
Montalvo-Casimiro, M:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 14080, DF, Mexico
Alvarez-López, DI:
Inst Nacl Cancerol, Unidad Epidemiol Canc, Mexico City 14080, Mexico
Reynoso-Noverón, N:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 14080, DF, Mexico
Inst Nacl Cancerol, Unidad Epidemiol Canc, Mexico City 14080, Mexico
Cuevas-Estrada, B:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 14080, DF, Mexico
Mendoza-Pérez, J:
Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA
Jiménez-Ríos, MA:
Inst Nacl Cancerol, Dept Urol, Mexico City 14080, Mexico
Wegman-Ostrosky, T:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 14080, DF, Mexico
Salcedo-Tello, P:
Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Mexico City 04510, Mexico
Scavuzzo, A:
Inst Nacl Cancerol, Dept Urol, Mexico City 14080, Mexico
Castro-Hernández, C:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 14080, DF, Mexico
Herrera, LA:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 14080, DF, Mexico
Tecnol Monterrey, Escuela Med & Ciencias Salud, Monterrey 64710, Mexico
González-Barrios, R:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 14080, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Ciencias, Dept Biol Celular, Mexico City 04510, Mexico
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