Genotypes of Sechium spp. as a Source of Natural Products with Biological Activity
Por:
Cadena-Iñiguez, J, Arévalo-Galarza, MD, Santiago-Osorio, E, Aguiñiga-Sánchez, I, Cadena-Zamudio, JD, Soto-Hernández, M, Ramírez-Rodas, YC, Ruiz-Posadas, LD, Salazar-Aguilar, S, Cisneros-Solano, VM
Publicada:
1 ene 2025
Resumen:
The genus Sechium P. Br. (Cucurbitaceae) includes ten species, two of which are edible. The inedible genotypes are in a fragile ecological niche, since they are not used by rural inhabitants. A rescue and genetic crossing program was designed to identify uses that favor their conservation due to their content of bioactive secondary metabolites (Sm) for health. Fruits of S. compositum (wild type), hybrid H-D Victor (inedible), and S. edule var. nigrum spinosum (edible) were evaluated by extraction methods such as juice and oven drying to determine the yields of Sm, with in vivo evaluations of liver damage. The dried biomass (40 degrees C) extracted with ethanolic and methanolic procedures showed lower Sm content than the juice (fresh biomass). More than 90% of phenolic acids and cucurbitacins in the extracts were degraded, possibly due to the drying time (oven). Biological activity showed that nigrum spinosum and HD-Victor have fewer toxic metabolites than S. compositum. The hybrid H-D Victor is of reduced cytotoxicity, showing the advantages of hybridization with wild types. Phytochemical and biological activity characterization may contribute to the conservation of genotypes and become a source of bioactive natural products.
Filiaciones:
Cadena-Iñiguez, J:
Col Postgrad, Campus San Luis Potosi, San Luis Potosi 78620, San Luis Potosi, Mexico
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Arévalo-Galarza, MD:
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Col Postgrad, Programa Bot & Fisiol, Campus Montecillo, Texcoco 56264, Estado De Mexic, Mexico
Santiago-Osorio, E:
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Univ Nacl Autonoma Mexico, Res Unit Cell Differentiat & Canc, Hematopoiesis & Leukemia Lab, FES Zaragoza, Mexico City 09230, Mexico
Aguiñiga-Sánchez, I:
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Univ Nacl Autonoma Mexico, Sch Med, Dept Biomed Sci, FES Zaragoza, Mexico City 09230, Mexico
Cadena-Zamudio, JD:
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Inst Nacl Invest Forestales Agr & Pecuarias, Ctr Nacl Recursos Genet, Blvd Biodivers 400 Rancho Cruces, Tepatitlan De Morelos 47600, Jalisco, Mexico
Soto-Hernández, M:
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Col Postgrad, Programa Bot & Fisiol, Campus Montecillo, Texcoco 56264, Estado De Mexic, Mexico
Ramírez-Rodas, YC:
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Inst Nacl Invest Forestales Agr & Pecuarias, Valles Cent,C. Melchor Ocampo 7,Sto. Domingo Barri, Etla 68200, Oaxaca, Mexico
Ruiz-Posadas, LD:
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Col Postgrad, Programa Bot & Fisiol, Campus Montecillo, Texcoco 56264, Estado De Mexic, Mexico
Salazar-Aguilar, S:
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Univ Nacl Autonoma Mexico, Res Unit Cell Differentiat & Canc, Hematopoiesis & Leukemia Lab, FES Zaragoza, Mexico City 09230, Mexico
Cisneros-Solano, VM:
Interdisciplinary Res Grp Sechium Edule Mexico AC, Agustin Melgar 10, Col Ninos Heroes, Estado Mex, Texcoco 56160, Estado De Mexic, Mexico
Univ Autonoma Chapingo, Ctr Reg Univ Oriente, Huatusco 94100, Veracruz, Mexico
gold, All Open Access; Gold Open Access
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