Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study
Por:
Denova-Gutiérrez, E, Rivera-Paredez, B, Quezada-Sánchez, AD, Armenta-Guirado, BI, Muñoz-Aguirre, P, Flores, YN, Velázquez-Cruz, R, Salmerón, J
Publicada:
1 ene 2025
Resumen:
Introduction and Objectives: Nonalcoholic fatty liver disease (NAFLD) is a common clinical condition and an important public health problem. Some epidemiological studies have suggested that soft drinks (SD) intake is associated with NAFLD. However, the evidence is inconsistent. Our objective was to assess the association between SD consumption and the risk of NAFLD in a Mexican adult population. Materials and Methods: A total of 1,759 participants from the Health Workers Cohort Study (HWCS) were included in the analyses. SD intake was measured using a validated food frequency questionnaire. We classified SD consumption as follows: a) less than 1 serving per week, b) 1 to less than 3.5 servings per week, and c) 3.5 or more servings per week. Hepatic steatosis index (HSI) was calculated based on sex, BMI, and blood transaminase levels, and was categorized as NAFLD >= 36. To assess the relation between SD and NAFLD, we followed two approaches: fixed effects logistic regression and generalized estimating equations. Results: After adjusting for demographic characteristics, lifestyle factors, and dietary intake, the odds ratio (OR) and 95 % confidence interval (95 % CI) for NAFLD were 1.26 (95 % CI: 1.08, 1.48) for 1 to less than 3.5 servings per week and 1.42(95% CI: 1.19, 1.69) for >= 3.5 servings/week category in both sexes. When stratifying the analysis by sex, we observed that the association tended to be greater in men than in women. Conclusions: The results from our prospective study indicate that SD consumption is associated with an increased risk of NAFLD. (c) 2024 Fundaci & oacute;n Cl & iacute;nica M & eacute;dica Sur, A.C. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Filiaciones:
Mexican Natl Inst Publ Hlth, Ctr Res Nutr & Hlth, Cuernavaca, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Ctr Res Pol Populat & Hlth, Mexico City, Mexico
Natl Inst Publ Hlth, Ctr Evaluat & Surveys Res, Cuernavaca, Mexico
Univ Sonora, Dept Hlth Sci, Hermosillo, Mexico
Natl Inst Publ Hlth, Consejo Nacl Humanidades Ciencias & Tecnol, Cuernavaca, Mexico
Natl Inst Publ Hlth, Ctr Populat Hlth Res, Cuernavaca, Mexico
Inst Mexicano Seguro Social, Unidad Invest Epidemiol & Serv Salud, Cuernavaca, Mexico
UCLA Dept Hlth Policy & Management, Ctr Canc Prevent, Los Angeles, CA USA
Fielding Sch Publ Hlth, UCLA Kaiser Permanente Ctr Hlth Equ, Los Angeles, CA USA
Jonsson Comprehens Canc Ctr, Los Angeles, CA USA
Natl Inst Genom Med, Genom Bone Metab Lab, Mexico City, Mexico
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