Metabolic dysregulation of tricarboxylic acid cycle and oxidative phosphorylation in glioblastoma
Por:
Trejo-Solis, C, Serrano-García, N, Castillo-Rodríguez, RA, Robledo-Cadena, DX, Jimenez-Farfan, D, Marín-Hernández, A, Silva-Adaya, D, Rodríguez-Pérez, CE, Gallardo-Pérez, JC
Publicada:
28 oct 2024
Ahead of Print:
1 jun 2024
Categoría:
Neuroscience (miscellaneous)
Resumen:
Glioblastoma multiforme (GBM) exhibits genetic alterations that induce the deregulation of oncogenic pathways, thus promoting metabolic adaptation. The modulation of metabolic enzyme activities is necessary to generate nucleotides, amino acids, and fatty acids, which provide energy and metabolic intermediates essential for fulfilling the biosynthetic needs of glioma cells. Moreover, the TCA cycle produces intermediates that play important roles in the metabolism of glucose, fatty acids, or non-essential amino acids, and act as signaling molecules associated with the activation of oncogenic pathways, transcriptional changes, and epigenetic modifications. In this review, we aim to explore how dysregulated metabolic enzymes from the TCA cycle and oxidative phosphorylation, along with their metabolites, modulate both catabolic and anabolic metabolic pathways, as well as pro-oncogenic signaling pathways, transcriptional changes, and epigenetic modifications in GBM cells, contributing to the formation, survival, growth, and invasion of glioma cells. Additionally, we discuss promising therapeutic strategies targeting key players in metabolic regulation. Therefore, understanding metabolic reprogramming is necessary to fully comprehend the biology of malignant gliomas and significantly improve patient survival.
Filiaciones:
Trejo-Solis, C:
Inst Nacl Neurol & Neurocirug, Lab Expt Enfermedades Neurodegenerat, Lab Neurobiol Mol & Celular, Lab Neurofarmacol Mol & Nanotecnol, Mexico City 14269, Mexico
Serrano-García, N:
Inst Nacl Neurol & Neurocirug, Lab Expt Enfermedades Neurodegenerat, Lab Neurobiol Mol & Celular, Lab Neurofarmacol Mol & Nanotecnol, Mexico City 14269, Mexico
Castillo-Rodríguez, RA:
Inst Politecn Nacl, Unidad Morelos, CICATA, Blvd Tecnol 1036 Z-1,P 2-2, Atlacholoaya 62790, Xochitepec, Mexico
Robledo-Cadena, DX:
Inst Nacl Cardiol, Dept Fisiopatol Cardiorenal, Dept Bioquim, Mexico City 14080, Mexico
Univ Nacl Autonoma Mexico, Fac Ciencias, Dept Biol Evolut, Mexico City 04510, Mexico
Jimenez-Farfan, D:
Univ Nacl Autonoma Mexico, Fac Odontol, Div Estudios Posgrad & Invest, Lab Inmunol, Mexico City 04510, Mexico
Marín-Hernández, A:
Inst Nacl Cardiol, Dept Fisiopatol Cardiorenal, Dept Bioquim, Mexico City 14080, Mexico
Univ Nacl Autonoma Mexico, Fac Ciencias, Dept Biol Evolut, Mexico City 04510, Mexico
Silva-Adaya, D:
Inst Nacl Neurol & Neurocirug, Lab Expt Enfermedades Neurodegenerat, Lab Neurobiol Mol & Celular, Lab Neurofarmacol Mol & Nanotecnol, Mexico City 14269, Mexico
Rodríguez-Pérez, CE:
Inst Nacl Neurol & Neurocirug, Lab Expt Enfermedades Neurodegenerat, Lab Neurobiol Mol & Celular, Lab Neurofarmacol Mol & Nanotecnol, Mexico City 14269, Mexico
Gallardo-Pérez, JC:
Inst Nacl Cardiol, Dept Fisiopatol Cardiorenal, Dept Bioquim, Mexico City 14080, Mexico
Univ Nacl Autonoma Mexico, Fac Ciencias, Dept Biol Evolut, Mexico City 04510, Mexico
hybrid, All Open Access; Hybrid Gold Open Access
|