Evaluation of differences in cardiovascular and metabolic effects of chronic caffeinated and decaffeinated coffee intake
Por:
López-Canales O.A., Ortiz-Hernández M., Lozano-Cuenca J., Herrera-Tolentino O.C., López-Canales J.S., Nicolás-Velázquez P., Paredes-Carbajal M.C.
Publicada:
1 ene 2024
Resumen:
Although coffee is one of the most popular beverages, the relationship between chronic consumption and cardiovascular health remains controversial. Therefore, this study investigated the effects of chronic consumption of caffeinated or decaffeinated coffee on biochemical profile and cardiovascular response. Three groups of rats were treated with HPLC characterized caffeinated or decaffeinated coffee and control for six weeks; blood pressure and biochemical profile were analyzed, followed by in vitro aortic ring experiments. The results showed that both coffees reduced blood glucose, AST and ALT. However, only caffeinated coffee elevated blood pressure in vivo, whereas aortic rings with endothelium increased the vasocontractile response; this effect was reversed by the addition of indomethacin and L-NAME also reduced the endothelium-mediated vasodilator response. In conclusion, chronic intake of any type of coffee positively improves biochemical profile. However, caffeinated coffee reduces nitric oxide biosynthesis and increases vasoconstrictor prostanoid production, whereas decaffeinated coffee preserves vascular function. © 2024
Filiaciones:
López-Canales O.A.:
Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Zip Code 04510, Mexico
Ortiz-Hernández M.:
Faculty of Science, National Autonomous University of Mexico, Mexico City, Zip Code 04510, Mexico
Lozano-Cuenca J.:
Department of Physiology and Cell Development, National Institute of Perinatology, Mexico City, Zip Code 11000, Mexico
Herrera-Tolentino O.C.:
Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Zip Code 04510, Mexico
López-Canales J.S.:
Department of Physiology and Cell Development, National Institute of Perinatology, Mexico City, Zip Code 11000, Mexico
Section of Postgraduate Studies, Higher School of Medicine, National Polytechnic Institute, Mexico City, Zip Code 11340, Mexico
Nicolás-Velázquez P.:
Department of Cellular and tissular Biology, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Zip Code 04510, Mexico
Paredes-Carbajal M.C.:
Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Zip Code 04510, Mexico
|