Metabolism and immune memory in invertebrates: are they dissociated?
Por:
Méndez-López T.T., Carrero J.C., Lanz-Mendoza H., Ochoa-Zarzosa A., Mukherjee K., Contreras-Garduño J.
Publicada:
1 ene 2024
Resumen:
Since the discovery of specific immune memory in invertebrates, researchers have investigated its immune response to diverse microbial and environmental stimuli. Nevertheless, the extent of the immune system’s interaction with metabolism, remains relatively enigmatic. In this mini review, we propose a comprehensive investigation into the intricate interplay between metabolism and specific immune memory. Our hypothesis is that cellular endocycles and epigenetic modifications play pivotal roles in shaping this relationship. Furthermore, we underscore the importance of the crosstalk between metabolism and specific immune memory for understanding the evolutionary costs. By evaluating these costs, we can gain deeper insights into the adaptive strategies employed by invertebrates in response to pathogenic challenges. Lastly, we outline future research directions aimed at unraveling the crosstalk between metabolism and specific immune memory. These avenues of inquiry promise to illuminate fundamental principles governing host-pathogen interactions and evolutionary trade-offs, thus advancing our understanding of invertebrate immunology. Copyright © 2024 Méndez-López, Carrero, Lanz-Mendoza, Ochoa-Zarzosa, Mukherjee and Contreras-Garduño.
Filiaciones:
Posgrado en Ciencias Biológicas, Escuela Nacional de Estudios Superiores, Unidad Morelia, Universidad Nacional Autónoma de México, Morelia, Mexico
Departmento de Immunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Instituto Nacional de Salud Pública, Departamento de Enfermedades Infecciosas, Cuernavaca, Mexico
Centro Multidisciplinario de Estudios en Biotecnología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico
Institute of Hygiene, University Hospital Müenster, University of Münster, Münster, Germany
Institute for Evolution and Biodiversity, University of Münster, Münster, Germany
Escuela Nacional de Estudios Superiores, Unidad Morelia, Universidad Nacional Autónoma de México, Morelia, Mexico
gold, All Open Access; Gold Open Access
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