Underlying Mechanisms of the Protective Effects of Lifestyle Factors in the Prevention of Age-Related Diseases
Por:
Alcaráz N., Salcedo-Tello P., González-Barrios R., Torres-Arciga K., Guzmán-Ramos K.
Publicada:
1 ene 2024
Ahead of Print:
1 jun 2024
Categoría:
Medicine (miscellaneous)
Resumen:
The rise in life expectancy has significantly increased the occurrence of age-related chronic diseases, leading to escalating expenses for both society and individuals. Among the main factors influencing health and lifespan, lifestyle takes a forefront position. Specifically, nutrition, mental activity, and physical exercise influence the molecular and functional mechanisms that contribute to the prevention of major age-related diseases. Gaining deeper insights into the mechanisms that drive the positive effects of healthy lifestyles is valuable for creating interventions to prevent or postpone the development of chronic degenerative diseases. This review summarizes the main mechanisms that underlie the positive effect of lifestyle factors in counteracting the major age-related diseases involving brain health, musculoskeletal function, cancer, frailty, and cardiovascular diseases, among others. This knowledge will help to identify high-risk populations for targeted intervention trials and discover new biomarkers associated with healthy aging. © 2024
Filiaciones:
Alcaráz N.:
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Salcedo-Tello P.:
Departamento de Bioquímica, Facultad de Medicina, Universidad Naçional Autónoma de México, Mexico City, Mexico
González-Barrios R.:
Instituto Nacional de Cancerología, Laboratorio de regulación de la cromatina y genómica, Mexico City, Mexico
Torres-Arciga K.:
Instituto Nacional de Cancerología, Laboratorio de regulación de la cromatina y genómica, Mexico City, Mexico
Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City, Mexico
Guzmán-Ramos K.:
Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana, Mexico State, Unidad Lerma, Mexico
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