The mitochondrial respiratory chain from Rhodotorula mucilaginosa, an extremophile yeast
Por:
Castañeda-Tamez P., Chiquete-Félix N., Uribe-Carvajal S., Cabrera-Orefice A.
Publicada:
1 ene 2024
Ahead of Print:
1 feb 2024
Resumen:
Rhodotorula mucilaginosa survives extreme conditions through several mechanisms, among them its carotenoid production and its branched mitochondrial respiratory chain (RC). Here, the branched RC composition was analyzed by biochemical and complexome profiling approaches. Expression of the different RC components varied depending on the growth phase and the carbon source present in the medium. R. mucilaginosa RC is constituted by all four orthodox respiratory complexes (CI to CIV) plus several alternative oxidoreductases, in particular two type-II NADH dehydrogenases (NDH2) and one alternative oxidase (AOX). Unlike others, in this yeast the activities of the orthodox and alternative respiratory complexes decreased in the stationary phase. We propose that the branched RC adaptability is an important factor for survival in extreme environmental conditions; thus, contributing to the exceptional resilience of R. mucilaginosa. © 2024 Elsevier B.V.
Filiaciones:
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, Netherlands
Radboud Center for Mitochondrial Medicine (RCMM), Radboud University Medical Center, Nijmegen, Netherlands
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