Clinical Cases of Coccidioidomycosis in the Americas in the Period 1950-2021: Epidemiology Data, Diagnosis, and Treatment


Por: Reyes-Montes, MD, León-García, AA, Frías-De-León, MG, Acosta-Altamirano, G, Sánchez-Saavedra, EP, Victoriano-Pastelín, I, Meraz-Ríos, B, Duarte-Escalante, E

Publicada: 1 nov 2023
Resumen:
Coccidioidomycosis, caused by Coccidioides immitis and C. posadasii, causes significant morbidity and mortality, both in immunocompetent and immunocompromised people, mainly in endemic areas. The present work analyzed its epidemiology, diagnostic methods, and treatment by reviewing clinical cases published from 1950 to 2021. Fifty-nine articles were included, corresponding to 275 clinical cases. The results showed a higher incidence of coccidioidomycosis in the male gender than the female gender. The most affected age group was 31-40 years, and the most reported clinical presentation was disseminated with greater involvement in cutaneous and subcutaneous tissue, followed by the CNS, bone system, and peritoneum. The species most frequently reported was C. immitis. The most used treatment was azoles, followed by their combination with amphotericin B, monotherapy with amphotericin B, and alternative medicine. This work shows that epidemiological data outside the USA are still scarce. Serological tests are the preferred diagnostic method in daily medical practice, and cultures remain the gold standard. The treatment for coccidioidomycosis is ketoconazole and amphotericin B, individually or in combination.

Filiaciones:
Reyes-Montes, MD:
 Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Ciudad Univ, Ciudad De Mexico 04510, Mexico

León-García, AA:
 Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Ciudad Univ, Ciudad De Mexico 04510, Mexico

Frías-De-León, MG:
 Hosp Reg Alta Especial Ixtapaluca, Unidad Invest Biomed, Ixtapaluca 56530, Mexico

Acosta-Altamirano, G:
 Hosp Reg Alta Especial Ixtapaluca, Unidad Invest Biomed, Ixtapaluca 56530, Mexico

Sánchez-Saavedra, EP:
 Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Ciudad Univ, Ciudad De Mexico 04510, Mexico

Victoriano-Pastelín, I:
 Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Ciudad Univ, Ciudad De Mexico 04510, Mexico

Meraz-Ríos, B:
 Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Ciudad Univ, Ciudad De Mexico 04510, Mexico

Duarte-Escalante, E:
 Univ Nacl Autonoma Mexico, Fac Med, Dept Microbiol & Parasitol, Ciudad Univ, Ciudad De Mexico 04510, Mexico
ISSN: 00243019
Editorial
MDPI AG, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, Suiza
Tipo de documento: Review
Volumen: 13 Número: 11
Páginas:
WOS Id: 001115260100001
ID de PubMed: 38004249
imagen gold, Green Published, All Open Access; Gold Open Access

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