Vitamin D levels in the pre- and post-COVID-19 pandemic periods in pediatric patients with chronic kidney disease
Por:
Parra-Ortega, I, Zurita-Cruz, JN, Ortiz-Flores, I, Romero-Navarro, B, Villasis-Keever, MA, Martínez, BL, Domínguez-Castillo, V, Romo-Vázquez, JC
Publicada:
3 nov 2023
Resumen:
IntroductionVitamin D (VD) deficiency is common in children with chronic kidney disease (CKD) because of multiple factors. During the coronavirus disease 2019 (COVID-19) pandemic, it increased because of medicine shortage and no enough medical service for patients with non-COVID-19 diseases.ObjectiveTo analyze the effects of the COVID-19 pandemic-related lockdown on the serum levels and status of 25-hydroxyvitamin D3 (25-[OH]D) in children with CKD.Materials and methodsThis retrospective study included patients (6-18 years old) who were diagnosed with CKD stage 2-5 and routinely measured for serum VD levels between May 2019 and December 2022. Serum 25-(OH)D levels were measured before, during, and after the pandemic (2019, 2020-2021, and 2022, respectively). The daily dose of cholecalciferol supplementation and the readjustment (if required) were recorded.ResultsThis study included 171 patients (median age: 12 years). Before the pandemic, the median serum VD level was 25.0 ng/mL (19.3% VD deficiency). Then, VD supplementation was adjusted to 400-1,200 UI daily in 98.8% (n = 169) of patients. During the pandemic, the median VD level decreased to 22.5 ng/mL (43.3% VD deficiency). Hence, the supplementation was readjusted, and after the pandemic, the level was 28.7 ng/mL (18.7% VD deficiency), indicating a statistically significant increase in serum VD levels from the prepandemic period (p = 0.007).ConclusionDecreased serum VD levels and increased VD deficiency frequency were observed in patients with CKD during the COVID-19 but improved after readjustment of supplementation.
Filiaciones:
Parra-Ortega, I:
Hosp Infantil Mexico Dr Federico Gomez, Minist Hlth SSA, Auxiliary Diagnost Serv, Mexico City, Mexico
Zurita-Cruz, JN:
Univ Nacl Autonoma Mexico, Hosp Infantil Mexico Federico Gomez, Fac Med, Mexico City, Mexico
Ortiz-Flores, I:
Univ Nacl Autonoma Mexico, Hosp Infantil Mexico Federico Gomez, Fac Med, Mexico City, Mexico
Romero-Navarro, B:
Hosp Infantil Mexico Dr Federico Gomez, Minist Hlth SSA, Auxiliary Diagnost Serv, Mexico City, Mexico
Villasis-Keever, MA:
Inst Mexicano Seguro Social, Natl Med Ctr 21 Century, Anal & Synth Evidence Res Unit, Mexico City, Mexico
Martínez, BL:
Labs Ruiz SYNLAB, Dept Teaching & Res, Mexico City, Mexico
Domínguez-Castillo, V:
Hosp Infantil Mexico Dr Federico Gomez, Minist Hlth SSA, Auxiliary Diagnost Serv, Mexico City, Mexico
Romo-Vázquez, JC:
Hosp Infantil Mexico Dr Federico Gomez, Minist Hlth SSA, Dept Pediat Nephol, Mexico City, Mexico
Green Published, gold, All Open Access; Gold Open Access; Green Open Access
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