Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases
Por:
Castillejos-Lopez, M, Romero, Y, Varela-Ordonez, A, Flores-Soto, E, Romero-Martinez, BS, Velazquez-Cruz, R, Vazquez-Perez, JA, Ruiz, V, Gomez-Verjan, JC, Rivero-Segura, NA, Camarena, A, Torres-Soria, AK, Gonzalez-Avila, G, Sommer, B, Solis-Chagoyan, H, Jaimez, R, Torres-Espindola, LM, Aquino-Galvez, A, Kalyuzhny, AE
Publicada:
1 dic 2023
Categoría:
Biochemistry, genetics and molecular biology (miscellaneous)
Resumen:
The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present in the body's tissues and helps regulate various processes such as sleeping, eating, and others. Interestingly, animal models have provided enough evidence to assume that the alteration in the circadian system leads to the appearance of numerous diseases. Alterations in breathing patterns in lung diseases can modify oxygenation and the circadian cycles; however, the response mechanisms to hypoxia and their relationship with the clock genes are not fully understood. Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulate the circadian cycles, the latter because hypoxia alters the production of melatonin and brain physiology. Additionally, the lack of oxygen alters the expression of clock genes, leading to an alteration in the regularity and precision of the circadian cycle. In this sense, hypoxia is a hallmark of a wide variety of lung diseases. In the present work, we intended to review the functional repercussions of hypoxia in the presence of asthma, chronic obstructive sleep apnea, lung cancer, idiopathic pulmonary fibrosis, obstructive sleep apnea, influenza, and COVID-19 and its repercussions on the circadian cycles.
Filiaciones:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Epidemiol Infectol Hosp, Mexico City 14080, Mexico
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, Mexico
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Red MEDICI, Carrera Med Cirujano, Mexico City 54090, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Mexico City 04510, Mexico
Inst Nacl Med Genomica INMEGEN, Lab Genom Metab Oseo, Mexico City 14610, Mexico
Inst Nacl Enferdades Resp Ismael Cosio Villegas IN, Lab Biol Mol Enfermedades Emergentes & EPOC, Mexico City 14080, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Biol Mol, Dept Fibrosis Pulm, Mexico City 14080, Mexico
Inst Politecn Nacl INP, Escuela Super Med, Secc Estudios Posgrad & Invest, Mexico City 11340, Mexico
Inst Nacl Geriatria INGER, Direcc Invest, Mexico City 10200, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Inmunobiol & Genet, Mexico City 14080, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Oncol Biomed, Mexico City 14080, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Invest Hiperreact Bronquial, Mexico City 14080, Mexico
Univ Autonoma Estado Morelos, Ctr Invest Ciencias Cognit, Lab Neurobiol Cognit, Cuernavaca 62209, Mexico
Inst Nacl Pediat INP, Lab Farmacol, Mexico City 04530, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Mexico City 04510, Mexico
gold, All Open Access; Gold
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