The Hypotensive and Vasodilatory Effects Observed in Rats Exposed to Chiranthodendron pentadactylon Larreat Flowers Can Be Attributed to Cyanidin 3-O-Glucoside
Por:
Escobar-Ramírez, JL, Santiago-Mejía, J, Soto-Núñez, M, Barrera-Vázquez, OS, Vargas-Querea, R, Magos-Guerrero, GA
Publicada:
1 dic 2023
Resumen:
Chiranthodendron pentadactylon Larreat is a tree native to southeastern Mexico and Guatemala. Its flower is used in Mexican folk medicine to treat a variety of diseases, including conditions of blood pressure. However, scientific information on its usefulness in this pathology is lacking. The present study evaluates the effect of a methanolic extract (ME) from the flower and its active constituents on heart rate (HR) and mean arterial pressure (MAP) in anesthetized rats (MAPHR). The study also analyzed the effects on rat-isolated aortic rings (RIAR) and the rat mesenteric arterial bed (MABR). Active fractions were chromatographed, which led to the isolation of cyanidin 3-O-glucoside (C3G) identified through HPLC. The Chiranthodendron pentadactylon flowers produced hypotensive and vasorelaxant effects associated with C3G. The vasorelaxant effect is a mechanism underlying the synthesis and release of nitric oxide (NO). Neither cholinergic receptors nor prostaglandins are involved. ME and C3G cause cardiovascular depression in anesthetized rats via cholinergic and prostanoid mechanisms. Our research expands the scientific understanding of the flowers on the rat cardiovascular system. This amplifies the appreciation of the flower's ethnomedicine employed to control blood pressure. However, researchers need to conduct toxicity studies to determine the safety of this plant.
Filiaciones:
Escobar-Ramírez, JL:
Univ Natl Autonomous Mexico, Fac Med, Dept Pharmacol, Mexico City 04510, Mexico
Santiago-Mejía, J:
Univ Natl Autonomous Mexico, Fac Med, Dept Pharmacol, Mexico City 04510, Mexico
Soto-Núñez, M:
Univ Natl Autonomous Mexico, Fac Med, Dept Pharmacol, Mexico City 04510, Mexico
Barrera-Vázquez, OS:
Univ Natl Autonomous Mexico, Fac Med, Dept Pharmacol, Mexico City 04510, Mexico
Vargas-Querea, R:
Univ Natl Autonomous Mexico, Fac Med, Dept Pharmacol, Mexico City 04510, Mexico
Magos-Guerrero, GA:
Univ Natl Autonomous Mexico, Fac Med, Dept Pharmacol, Mexico City 04510, Mexico
gold, All Open Access, Gold
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