The immunomodulatory and antioxidant effects of ß-glucans in invertebrates


Por: Guluarte C., Pereyra A., Ramírez-Hernández E., Zenteno E., Luis Sánchez-Salgado J.

Publicada: 1 ene 2023 Ahead of Print: 1 nov 2023
Categoría: Ecology, evolution, behavior and systematics

Resumen:
ß-glucans (ßGs) are carbohydrate polymers linked by ß-1,3, 1,4 or 1,6 bonds, they have been used to protect against potential pathogens and prevent lethal diseases. The immune system possesses several receptors that identify a wide range of structures and trigger cellular and humoral mechanisms. However, the mechanisms by which ßGs activate the immune system of invertebrate organisms have not been fully clarified. This review is focused on evaluating the effect of ßGs on innate immune system in invertebrates. ßGs stimulate different cellular and humoral mechanisms, such as phagocytosis, oxygen species production, extracellular trap formation, proPO system, and antimicrobial peptide synthesis, moreover, ßGs increase survival rate and decrease pathogen load in several species. © 2023 Elsevier Inc.

Filiaciones:
Guluarte C.:
 Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, CP 04510, Mexico

Pereyra A.:
 Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, CP 04510, Mexico

Ramírez-Hernández E.:
 Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, CP 04510, Mexico

Zenteno E.:
 Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, CP 04510, Mexico

Luis Sánchez-Salgado J.:
 Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, CP 04510, Mexico
ISSN: 00222011
Editorial
ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, Estados Unidos America
Tipo de documento: Review
Volumen: 201 Número:
Páginas:
WOS Id: 001125648300001
ID de PubMed: 37984608

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