LC-MS Fingerprinting Development for Standardized Precipitate from Agastache mexicana, Which Induces Antihypertensive Effect through NO Production and Calcium Channel Blockade
Por:
Cruz-Torres, Karla Catalina, Estrada-Soto, Samuel, Arias-Duran, Luis, Navarrete-Vazquez, Gabriel, Almanza-Perez, Julio Cesar, Mora-Ramiro, Beatriz, Perea-Arango, Irene, Hernandez-Nunez, Emanuel, Villalobos-Molina, Rafael, Carmona-Castro, Gabriela, Medina-Díaz I.-M., avila-Villarreal, Gabriela
Publicada:
1 sep 2023
Categoría:
Pharmaceutical science
Resumen:
The aim of this work was to evaluate the vasorelaxant and
antihypertensive effects of a standardized precipitate of the
hydroalcoholic extract from Agastache mexicana (PPAm), comprising
ursolic acid, oleanolic acid, acacetin, luteolin and tilianin, among
others. In the ex vivo experiments, preincubation with L-NAME
(nonspecific inhibitor of nitric oxide synthases) reduced the relaxation
induced by PPAm; nevertheless, preincubation with indomethacin
(nonspecific inhibitor of cyclooxygenases) did not generate any change
in the vasorelaxation, and an opposed effect was observed to the
contraction generated by CaCl2 addition. Oral administration of 100
mg/kg of PPAm induced a significant acute decrease in diastolic (DBP)
and systolic (SBP) blood pressure in spontaneously hypertensive rats,
without changes in heart rate. Additionally, PPAm showed a sustained
antihypertensive subacute effect on both DBP and SBP for 10 days
compared to the control group. On the other hand, human umbilical vein
cells treated with 10 mu g/mL of PPAm showed a significant reduction (p
< 0.05) in intracellular adhesion molecule-1, compared to the control,
but not on vascular cell adhesion molecule-1. In conclusion, PPAm
induces a significant antihypertensive effect in acute- and
subacute-period treatments, due to its direct vasorelaxant action on rat
aortic rings through NO production and Ca2+ channel blockade.
Filiaciones:
Cruz-Torres, Karla Catalina:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Morelos, Cuernavaca, 62209, Mexico
Estrada-Soto, Samuel:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Morelos, Cuernavaca, 62209, Mexico
Arias-Duran, Luis:
Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Iztapalapa, Ciudad de Mexico, 09340, Mexico
Navarrete-Vazquez, Gabriel:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Morelos, Cuernavaca, 62209, Mexico
Almanza-Perez, Julio Cesar:
Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Iztapalapa, Ciudad de Mexico, 09340, Mexico
Mora-Ramiro, Beatriz:
Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Iztapalapa, Ciudad de Mexico, 09340, Mexico
Perea-Arango, Irene:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Morelos, Cuernavaca, 62209, Mexico
Hernandez-Nunez, Emanuel:
Departamento de Recursos del Mar, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Mérida, Yucatán, Mérida, 97310, Mexico
Villalobos-Molina, Rafael:
Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de Mexico, Estado de Mexico, Tlalnepantla, 54090, Mexico
Carmona-Castro, Gabriela:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Morelos, Cuernavaca, 62209, Mexico
Medina-Díaz I.-M.:
Laboratorio de Contaminación y Toxicología Ambiental, Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, Nayarit, Tepic, 63000, Mexico
avila-Villarreal, Gabriela:
Centro Nayarita de Innovación y Transferencia de Tecnología “Unidad Especializada en I+D+i en Calidad de Alimentos y Productos Naturales”, Universidad Autónoma de Nayarit, Nayarit, Tepic, 63000, Mexico
Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, Universidad Autónoma de Nayarit, Nayarit, Tepic, 63000, Mexico
gold, All Open Access; Gold
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