Prognosis of Mesorectal Tumor Deposits in Patients with Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy and Total Mesorectal Excision
Por:
Aguilar-Romero J.M., Aguilar-Romero E., Vergara-Fernández O., Zepeda-Najar C., Lino-Silva L.S., Salcedo-Hernández R.A.
Publicada:
1 ene 2023
Ahead of Print:
1 abr 2022
Resumen:
Background: Tumor deposits (TDs) are associated with adverse prognostic factors and decreased survival in colon cancer. However, there is no information of their survival impact in rectal cancer with neoadjuvant chemoradiotherapy (n-CRT). Methods: Retrospective study in 223 patients with rectal cancer with n-CRT. A survival analysis of factors associated with decreased overall survival (OS) including TDs was performed. Results: From 223 patients, 131 (58.7%) were men, mean age 59.8 (± 13.06) years, and 42 (18.8%) of them revealed TDs. Survival analysis of TDs showed no association with mortality. Factors associated with decreased 5-year OS were the histologic grade (p = 0.42), perineural invasion (p = 0.001), and mesorectal quality (p = 0.067). Perineural invasion (HR = 2.335, 95% CI = 1.198–4.552) remained as independent factor in the multivariate analysis. Conclusions: TDs were not associated with mortality in rectal cancer patients treated with n-CRT. Factors associated with decreased survival were inadequate mesorectal quality and perineural invasion. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Filiaciones:
General Surgery, Instituto Nacional de Ciencias Médicas Y de La Nutrición Salvador Zubrán, Mexico City, Mexico
Colorectal Surgery Division, Instituto Nacional de Ciencias Médicas y de La Nutrición Salvador Zubrán, Mexico City, Mexico
AFINES Program, National Autonomus University of Mexico (UNAM), Mexico City, Mexico
Surgical Pathology, Instituto Nacional de Cancerología, Av. San Fernando # 22, Sección XVI, Tlalpan, CP, Mexico City, 14080, Mexico
Surgical Oncology, Hospital Ángeles Tijuana, Tijuana, Baja California Norte, Mexico
Surgical Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico
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