IAEA randomised trial of optimal single dose radiotherapy in the treatment of painful bone metastases
Por:
Hoskin P., Rojas A., Fidarova E., Jalali R., Mena Merino A., Poitevin A., Oucrif S., Abdelwahab S., Kochbati L., Plieskiene A., Casas F., Stojanovic S., Schneider G., Jeremic B.
Publicada:
1 ene 2015
Resumen:
Abstract Background To determine the optimal single-dose radiotherapy schedule for pain from bone metastases in a multi-centre, international, randomised trial. Patients and methods 651 patients were randomised to either 8 Gy (n = 325) or 4 Gy (n = 326) radiotherapy. Pain at 4, 8, 12, 24 and 52 weeks was assessed using a Categorical Scale (CS) and a Visual Analogue Scale (VAS). The primary endpoint was response at 4 weeks. Results There was no significant difference in patient demographics and other co-variates. The complete response (CR) rate and ORR (complete or partial response) for all follow-up times were higher after 8 Gy (p = 0.02). The Kaplan-Meier actuarial rate (categorical scale) at 4 weeks for ORR was 80% after 8 Gy compared to 68% after 4 Gy (p = 0.0015). 117 re-treatments were given of which 72 were in the 4 Gy group and 45 in 8 Gy arm (p = 0.01). Conclusions There was a marked consistent difference in pain relief at all time points in favour of 8 Gy. These data reinforce the case for single dose 8 Gy radiotherapy to be recommended for metastatic bone pain in all healthcare settings. © 2015 Elsevier Ireland Ltd.
Filiaciones:
Hoskin P.:
Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex, HA6 2RN, United Kingdom
Rojas A.:
Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex, HA6 2RN, United Kingdom
Fidarova E.:
IAEA, Division of Human HealthVienna, Austria
Jalali R.:
Tata Memorial Hospital, Mumbai, India
Mena Merino A.:
Hospital Son Dureta, Palmas de Mallorca, Spain
Poitevin A.:
Instituto Nacional CancerologíaMéxico DF, Mexico
Oucrif S.:
Dep. Radiothérapie, Centre Hospitalier UniversitaireAlger, Algeria
Abdelwahab S.:
Misr Oncology CentreCairo, Egypt
Kochbati L.:
Radiotherapie carcinologique, Institut Salah AzaizTunis, Tunisia
Plieskiene A.:
Institute of Oncology, Vilnius University, Lithuania
Casas F.:
Radiation Oncology, Hospital Clínic i UniversitariBarcelona, Spain
Stojanovic S.:
Institute of Oncology and RadiologyBelgrade, Serbia
Schneider G.:
Fundacao Faculdade Federal de Ciencias Medicas, Porto Alegre, Brazil
Jeremic B.:
IAEA, Division of Human HealthVienna, Austria
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