Seroprevalence of SARS-CoV-2 in Mexican Health Care Workers after Two Years of the Pandemic: The Picture of an Ophthalmic Medical Centre
Por:
Garfias, Yonathan, Sofia Magana-Guerrero, Fatima, Buentello-Volante, Beatriz, Cruz Vega, Itayetzin Beurini, Islas-Castro, Ilse, Sanchez Cisneros, Paola de Jesus, Aguayo Flores, Jose Eduardo, Salas Lais, Angel Gustavo, Munoz Medina, Jose Esteban, Mata-Haro, Veronica, Resendiz-Sandoval, Monica, A Vazquez-Garcia, Veronica, Hernandez, Jesus
Publicada:
4 jul 2023
Ahead of Print:
1 oct 2022
Resumen:
Objective In this study, we investigated the impact of the SARS-CoV-2
vaccination on seroprevalence in a cohort of healthcare workers (HCW) at
an ophthalmic medical center. Methods IgG antibodies against the N, S1,
and S2 antigens of SARS-CoV-2 as well as their serum neutralizing
activity were determined. Results In the present study, we observed that
98.4% of HCW were seropositive for S1/S2 proteins of SARS-CoV-2 due to
the national vaccination program. Interestingly, 78.4% of the
participants had anti-N protein antibodies, suggesting previous COVID-19
infection. We also evaluated the neutralizing antibodies and found that
the mean value was high (90.7%). Conclusion These results indicate that
our HCWs cohort presented a robust hybrid humoral response owing to the
massive national vaccination program and natural infections.
Filiaciones:
Conde de Valenciana Fdn, Inst Ophthalmol, Res Unit, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Mexico City, DF, Mexico
IMSS, Inst Mexicano Seguro Social, Coordinac Calidad Insumos & Labs Especializados, Ciudad De Mexico, Mexico
Inst Mexicano Seguro Social, Coordinac Calidad Insumos & Labs Especializados, Mexico City, DF, Mexico
Ctr Invest Alimentac & Desarrollo AC CIAD, Lab Microbiol & Inmunol, Hermosillo, Sonora, Mexico
Ctr Invest Alimentac & Desarrollo AC CIAD, Lab Inmunol, Carretera Gustavo Enrique Astiazaran Rosas 46, Hermosillo 83304, Sonora, Mexico
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