Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients
Por:
Fierro N.A., González-Aldaco K., Torres-Valadez R., Trujillo-Trujillo M.E., Roman S., Trujillo-Ochoa J.L., Panduro A.
Publicada:
1 ene 2015
Resumen:
The mechanisms related to the spontaneous clearance of hepatitis C virus (HCV) have been primarily studied in regions where the infection is endemic. Results of prior studies have been extrapolated to populations with low endemicity, such as Mexico. Herein, we determined the cytokine profiles in serum samples from Mexican patients who spontaneously cleared HCV and patients chronically infected with HCV genotype 1a. Chronic HCV-infected patients displayed increased interleukin (IL)-8 and regulated upon activation, normal T-cell expressed and secreted (CCL-5) secretion, whereas patients who spontaneously cleared HCV showed augmented levels of IL-1 alpha, tumour necrosis factor-alpha, transforming growth factor-beta, monocyte chemoattractant protein-2 (CCL-8), IL-13 and IL-15. Our study suggests that cytokine profiles may predict disease outcome during HCV infection. © 2015, Fundacao Oswaldo Cruz. All rights reserved.
Filiaciones:
Unidad de Inmunovirología, Guadalajara, Jalisco, Mexico
Departamento de Fisiologia, Guadalajara, Jalisco, Mexico
Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico
Departamento de Biología Molecular, Guadalajara, Jalisco, Mexico
Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
All Open Access, Gold
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