Transcriptome-Wide Analysis of Low-Concentration Exposure to Bisphenol A, S, and F in Prostate Cancer Cells
Por:
Cortes-Ramirez, Sergio A., Salazar, Ana M., Sordo, Monserrat, Ostrosky-Wegman, Patricia, Morales-Pacheco, Miguel, Cruz-Burgos, Marian, Losada-Garcia, Alberto, Rodriguez-Martinez, Griselda, Gonzalez-Ramirez, Imelda, Vazquez-Santillan, Karla, Gonzalez-Covarrubias, Vanessa, Maldonado-Lagunas, Vilma, Rodriguez-Dorantes, Mauricio
Publicada:
30 may 2023
Resumen:
Bisphenol A (BPA) is a ubiquitous synthetic compound used as a monomer
in the production of polycarbonate plastics and epoxy resins. Even at
low doses, BPA has been associated with the molecular progression of
diseases such as obesity, metabolic syndrome, and hormone-regulated
cancers due to its activity as an endocrine-disrupting chemical (EDC).
Consequently, the use of BPA has been regulated worldwide by different
health agencies. BPA structural analogs such as bisphenol S and
bisphenol F (BPS and BPF) have emerged as industrial alternatives, but
their biological activity in the molecular progression of cancer remains
unclear. Prostate cancer (PCa) is a hormone-dependent cancer, and the
role of BPA structural analogs in PCa progression is still undescribed.
In this work, we use an in vitro model to characterize the
transcriptomic effect of low-concentration exposure to bisphenol A, S,
or F in the two main stages of the disease: androgen dependency (LNCaP)
and resistance (PC-3). Our findings demonstrated that the low
concentration exposure to each bisphenol induced a differential effect
over PCa cell lines, which marks the relevance of studying the effect of
EDC compounds through all the stages of the disease.
Filiaciones:
Cortes-Ramirez, Sergio A.:
Laboratorio de Oncogenómica, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genomica, Lab Oncogen, Mexico City 14610, Mexico
Salazar, Ana M.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Mexico City, 70228, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Ciudad Univ, Mexico City 70228, Mexico
Sordo, Monserrat:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Mexico City, 70228, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Ciudad Univ, Mexico City 70228, Mexico
Ostrosky-Wegman, Patricia:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Mexico City, 70228, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Ciudad Univ, Mexico City 70228, Mexico
Morales-Pacheco, Miguel:
Laboratorio de Oncogenómica, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genomica, Lab Oncogen, Mexico City 14610, Mexico
Cruz-Burgos, Marian:
Laboratorio de Oncogenómica, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genomica, Lab Oncogen, Mexico City 14610, Mexico
Losada-Garcia, Alberto:
Laboratorio de Oncogenómica, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genomica, Lab Oncogen, Mexico City 14610, Mexico
Rodriguez-Martinez, Griselda:
Laboratorio de Oncogenómica, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genomica, Lab Oncogen, Mexico City 14610, Mexico
Gonzalez-Ramirez, Imelda:
Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, 04960, Mexico
Univ Autonoma Metropolitana Xochimilco, Dept Atenc Salud, Mexico City 04960, Mexico
Vazquez-Santillan, Karla:
Laboratorio de Innovación en Medicina de Precisión, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genom, Lab Innovac Med Precis, Mexico City 14610, Mexico
Gonzalez-Covarrubias, Vanessa:
Laboratorio de Farmacogenómica, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, 14610, Mexico
Inst Nacl Med Genom INMEGEN, Lab Farmacogenom, Mexico City 14610, Mexico
Maldonado-Lagunas, Vilma:
Laboratorio de Epigenética, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genom, Lab Epigenet, Mexico City 14610, Mexico
Rodriguez-Dorantes, Mauricio:
Laboratorio de Oncogenómica, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Inst Nacl Med Genomica, Lab Oncogen, Mexico City 14610, Mexico
gold, Green Published, All Open Access, Gold, Green
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