Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
Por:
Berumen, Jaime, Orozco, Lorena, Gallardo-Rincon, Hector, Rivas, Fernando, Barrera, Elizabeth, Benuto, Rosa E., Garcia-Ortiz, Humberto, Marin-Medina, Melissa, Juarez-Torres, Eligia, Alvarado-Silva, Anabel, Ramos-Martinez, Espiridion, Martinez-Juarez, Luis Alberto, Lomelin-Gascon, Julieta, Montoya, Alejandra, Ortega-Montiel, Janinne, Alvarez-Hernández D.-A., Larriva-Shad, Jorge, Tapia-Conyer, Roberto
Publicada:
1 ene 2023
Resumen:
Background: This study investigated the effect of sex and age at type 2 diabetes (T2D) diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on T2D development. Methods: In this case–control study, 1012 T2D cases and 1008 healthy subjects were selected from the Diabetes in Mexico Study database. Participants were stratified by sex and age at T2D diagnosis (early, = 45 years; late, = 46 years). Sixty-nine T2D-associated single nucleotide polymorphisms were explored and the percentage contribution (R 2) of T2D-related genes, parental history of T2D, and obesity (body mass index [BMI] and waist–hip ratio [WHR]) on T2D development was calculated using univariate and multivariate logistic regression models. Results: T2D-related genes influenced T2D development most in males who were diagnosed early (R 2 = 23.5%; females, R 2 = 13.5%; males and females diagnosed late, R 2 = 11.9% and R 2 = 7.3%, respectively). With an early diagnosis, insulin production-related genes were more influential in males (76.0% of R 2) while peripheral insulin resistance-associated genes were more influential in females (52.3% of R 2). With a late diagnosis, insulin production-related genes from chromosome region 11p15.5 notably influenced males while peripheral insulin resistance and genes associated with inflammation and other processes notably influenced females. Influence of parental history was higher among those diagnosed early (males, 19.9%; females, 17.5%) versus late (males, 6.4%; females, 5,3%). Unilateral maternal T2D history was more influential than paternal T2D history. BMI influenced T2D development for all, while WHR exclusively influenced males. Conclusions: The influence of T2D-related genes, maternal T2D history, and fat distribution on T2D development was greater in males than females. © 2023, The Author(s).
Filiaciones:
Berumen, Jaime:
Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Cuauhtémoc, Ciudad de Mexico, 06720, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Ciudad De Mexico 06720, Mexico
Orozco, Lorena:
Instituto Nacional de Medicina Genómica, Ciudad de Mexico, Mexico
Inst Nacl Med Genom, Ciudad De Mexico, Mexico
Gallardo-Rincon, Hector:
Universidad of Guadalajara, Health Sciences University Center, Jalisco, Guadalajara, Mexico
Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, Mexico City, 11529, Mexico
Univ Guadalajara, Hlth Sci Univ Ctr, Guadalajara, Jalisco, Mexico
Fdn Carlos Slim, Lago Zurich 245, Presa Falcon Bldg,Floor 20,Col Am, Mexico City 11529, Mexico
Rivas, Fernando:
Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Cuauhtémoc, Ciudad de Mexico, 06720, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Ciudad De Mexico 06720, Mexico
Barrera, Elizabeth:
Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Cuauhtémoc, Ciudad de Mexico, 06720, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Ciudad De Mexico 06720, Mexico
Benuto, Rosa E.:
Laboratorio Huella Génica, Ciudad de Mexico, Mexico
Lab Huella Genica, Ciudad De Mexico, Mexico
Garcia-Ortiz, Humberto:
Instituto Nacional de Medicina Genómica, Ciudad de Mexico, Mexico
Inst Nacl Med Genom, Ciudad De Mexico, Mexico
Marin-Medina, Melissa:
Laboratorio Huella Génica, Ciudad de Mexico, Mexico
Lab Huella Genica, Ciudad De Mexico, Mexico
Juarez-Torres, Eligia:
Laboratorio Huella Génica, Ciudad de Mexico, Mexico
Lab Huella Genica, Ciudad De Mexico, Mexico
Alvarado-Silva, Anabel:
Laboratorio Huella Génica, Ciudad de Mexico, Mexico
Lab Huella Genica, Ciudad De Mexico, Mexico
Ramos-Martinez, Espiridion:
Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Cuauhtémoc, Ciudad de Mexico, 06720, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Ciudad De Mexico 06720, Mexico
Martinez-Juarez, Luis Alberto:
Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, Mexico City, 11529, Mexico
Fdn Carlos Slim, Lago Zurich 245, Presa Falcon Bldg,Floor 20,Col Am, Mexico City 11529, Mexico
Lomelin-Gascon, Julieta:
Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, Mexico City, 11529, Mexico
Fdn Carlos Slim, Lago Zurich 245, Presa Falcon Bldg,Floor 20,Col Am, Mexico City 11529, Mexico
Montoya, Alejandra:
Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, Mexico City, 11529, Mexico
Fdn Carlos Slim, Lago Zurich 245, Presa Falcon Bldg,Floor 20,Col Am, Mexico City 11529, Mexico
Ortega-Montiel, Janinne:
Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, Mexico City, 11529, Mexico
Fdn Carlos Slim, Lago Zurich 245, Presa Falcon Bldg,Floor 20,Col Am, Mexico City 11529, Mexico
Alvarez-Hernández D.-A.:
Fundación Carlos Slim, Lago Zurich 245, Presa Falcon Building (Floor 20), Col. Ampliacion Granada, Miguel Hidalgo, Mexico City, 11529, Mexico
Larriva-Shad, Jorge:
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Juriquilla, Mexico
Univ Nacl Autonoma Mexico, Inst Neurobiol, Juriquilla, Queretaro, Mexico
Tapia-Conyer, Roberto:
Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Ciudad De Mexico, Mexico
gold, All Open Access; Gold
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