Subchronic co-exposure to particulate matter and fructose-rich-diet induces insulin resistance in male Sprague Dawley rats
Por:
Jimenez-Chavez, Arturo, Morales-Rubio, Russell, Sanchez-Gasca, Eliu, Rivera-Rosas, Monica, Uribe-Ramirez, Marisela, Amador-Munoz, Omar, Martinez-Dominguez, Y. Margarita, Rosas-Perez, Irma, Choy, Elizabeth H., Herman, David A., Kleinman, Michael T., De Vizcaya-Ruiz, Andrea
Publicada:
1 jun 2023
Resumen:
Insulin resistance (IR) and metabolic disorders are non-pulmonary
adverse effects induced by fine particulate matter (PM2.5) exposure. The
worldwide pandemic of high fructose sweeteners and fat rich modern
diets, also contribute to IR development. We investigated some of the
underlying effects of IR, altered biochemical insulin action and
Insulin/AKT pathway biomarkers. Male Sprague Dawley rats were
subchronically exposed to filtered air, PM2.5, a fructose rich diet
(FRD), or PM2.5 + FRD. Exposure to PM2.5 or FRD alone did not induce
metabolic changes. However, PM2.5 + FRD induced leptin release, systemic
hyperinsulinemia, and Insulin/AKT dysregulation in insulin-sensitive
tissues preceded by altered AT1R levels. Histological damage and
increased HOMA-IR were also observed from PM2.5 + FRD co-exposure. Our
results indicate that the concomitant exposure to a ubiquitous
environmental pollutant, such as PM2.5, and a metabolic disease risk
factor, a FRD, can contribute to the metabolic disorder pandemic
occurring in highly polluted locations.
Filiaciones:
Jimenez-Chavez, Arturo:
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Ciudad de México, Mexico
Ctr Invest & Estudios Avanzados IPN CINVESTAV IPN, Dept Toxicol, Ciudad De Mexico, Mexico
Morales-Rubio, Russell:
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Ciudad de México, Mexico
Ctr Invest & Estudios Avanzados IPN CINVESTAV IPN, Dept Toxicol, Ciudad De Mexico, Mexico
Sanchez-Gasca, Eliu:
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Ciudad de México, Mexico
Ctr Invest & Estudios Avanzados IPN CINVESTAV IPN, Dept Toxicol, Ciudad De Mexico, Mexico
Rivera-Rosas, Monica:
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Ciudad de México, Mexico
Ctr Invest & Estudios Avanzados IPN CINVESTAV IPN, Dept Toxicol, Ciudad De Mexico, Mexico
Uribe-Ramirez, Marisela:
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Ciudad de México, Mexico
Ctr Invest & Estudios Avanzados IPN CINVESTAV IPN, Dept Toxicol, Ciudad De Mexico, Mexico
Amador-Munoz, Omar:
Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Inst Ciencias Atmosfera & Cambio Climat, Ciudad Univ, Ciudad De Mexico, Mexico
Martinez-Dominguez, Y. Margarita:
Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Inst Ciencias Atmosfera & Cambio Climat, Ciudad Univ, Ciudad De Mexico, Mexico
Rosas-Perez, Irma:
Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, Mexico
Univ Nacl Autonoma Mexico, Inst Ciencias Atmosfera & Cambio Climat, Ciudad Univ, Ciudad De Mexico, Mexico
Choy, Elizabeth H.:
Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California Irvine, Irvine, CA, United States
Univ Calif Irvine, Susan & Henry Samueli Coll Hlth Sci, Dept Environm & Occupat Hlth, Program Publ Hlth, Irvine, CA 92697 USA
Herman, David A.:
Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California Irvine, Irvine, CA, United States
Univ Calif Irvine, Susan & Henry Samueli Coll Hlth Sci, Dept Environm & Occupat Hlth, Program Publ Hlth, Irvine, CA 92697 USA
Kleinman, Michael T.:
Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California Irvine, Irvine, CA, United States
Univ Calif Irvine, Susan & Henry Samueli Coll Hlth Sci, Dept Environm & Occupat Hlth, Program Publ Hlth, Irvine, CA 92697 USA
De Vizcaya-Ruiz, Andrea:
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), Ciudad de México, Mexico
Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California Irvine, Irvine, CA, United States
Ctr Invest & Estudios Avanzados IPN CINVESTAV IPN, Dept Toxicol, Ciudad De Mexico, Mexico
Univ Calif Irvine, Susan & Henry Samueli Coll Hlth Sci, Dept Environm & Occupat Hlth, Program Publ Hlth, Irvine, CA 92697 USA
Ave Inst Politecn Nacl 2508, Mexico City 07360, DF, Mexico
hybrid, Hybrid Gold
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