Modulatory role of prolactin in type 1 diabetes
Por:
Ramos-Martinez, Edgar, Ramos-Martinez, Ivan, Valencia, Jorge, Ramos-Martinez, Juan Carlos, Hernandez-Zimbron, Luis, Rico-Luna, Anaiza, Perez-Campos, Eduardo, Perez-Campos Mayoral, Laura, Cerbon, Marco
Publicada:
1 ene 2023
Ahead of Print:
1 jul 2022
Resumen:
Objectives: Patients with type 1 diabetes mellitus have been reported to have elevated prolactin levels and a possible relationship between prolactin levels and the development of the disease has been proposed. However, some studies show that prolactin mediates beneficial functions in beta cells. Therefore, we review information on the roles of prolactin in type 1 diabetes mellitus. Content: Here we summarize the functions of prolactin in the immune system and in pancreatic beta cells, in addition, we describe studies related to PRL levels, its regulation and alterations of secretion in patients with type 1 diabetes mellitus. Summary: Studies in murine models have shown that prolactin protects beta cells from apoptosis, stimulates their proliferation and promotes pancreatic islet revascularization. In addition, some studies in patients with type 1 diabetes mellitus have shown that elevated prolactin levels correlate with better disease control. Outlook: Prolactin treatment appears to be a promising strategy to improve beta-cell vascularization and proliferation in transplantation and immunotherapies. © 2022 the author(s), published by De Gruyter, Berlin/Boston.
Filiaciones:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Departamento de Medicina y Zootecnia de Cerdos, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Endocrine Research Unit, UMAE, Hospital de Especialidades, Instituto Mexicano Del Seguro Social, Ciudad de México, Mexico
Cardiology Department, Hospital General Regional Lic Ignacio Garcia Tellez, IMSS, Yucatán, Mérida, Mexico
Escuela Nacional de Estudios Superiores, Licenciatura en Optometría, Unidad León, Universidad, Nacional Autónoma de México, Ciudad de México, Mexico
Tecnológico Nacional de México/ ITOaxaca, Oaxaca, Mexico
Research Centre Medicine UNAM-UABJO. Facultad de Medicina, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca, Mexico
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
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