MiRNAs in Hematopoiesis and Acute Lymphoblastic Leukemia
Por:
Mendiola-Soto, Diana Karen, Barcenas-Lopez, Diego Alberto, Perez-Amado, Carlos Jhovani, Cruz-Miranda, Gabriela Marisol, Mejia-Arangure, Juan Manuel, Ramirez-Bello, Julian, Hidalgo-Miranda, Alfredo, Jimenez-Morales, Silvia
Publicada:
1 mar 2023
Resumen:
Acute lymphoblastic leukemia (ALL) is the most common kind of pediatric
cancer. Although the cure rates in ALL have significantly increased in
developed countries, still 15-20% of patients relapse, with even higher
rates in developing countries. The role of non-coding RNA genes as
microRNAs (miRNAs) has gained interest from researchers in regard to
improving our knowledge of the molecular mechanisms underlying ALL
development, as well as identifying biomarkers with clinical relevance.
Despite the wide heterogeneity reveled in miRNA studies in ALL,
consistent findings give us confidence that miRNAs could be useful to
discriminate between leukemia linages, immunophenotypes, molecular
groups, high-risk-for-relapse groups, and poor/good responders to
chemotherapy. For instance, miR-125b has been associated with prognosis
and chemoresistance in ALL, miR-21 has an oncogenic role in lymphoid
malignancies, and the miR-181 family can act either as a oncomiR or
tumor suppressor in several hematological malignancies. However, few of
these studies have explored the molecular interplay between miRNAs and
their targeted genes. This review aims to state the different ways in
which miRNAs could be involved in ALL and their clinical implications.
Filiaciones:
Mendiola-Soto, Diana Karen:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Barcenas-Lopez, Diego Alberto:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Programa de Doctorado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Perez-Amado, Carlos Jhovani:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Programa de Maestría y Doctorado, Posgrado en Ciencias Bioquímicas, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Cruz-Miranda, Gabriela Marisol:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Programa de Doctorado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Mejia-Arangure, Juan Manuel:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Ramirez-Bello, Julian:
Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, 14080, Mexico
Hidalgo-Miranda, Alfredo:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
Jimenez-Morales, Silvia:
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, 14610, Mexico
gold, Green Published, All Open Access, Gold, Green
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