Mitochondrial function and cardioprotection
Por:
Luna-Ortiz P., El-Hafidi M., Martínez-Rosas M.
Publicada:
1 ene 2013
Categoría:
Anesthesiology and Pain Medicine
Resumen:
Mitochondria play an important role in energy metabolism within the cell. Also are known to be intimately involved in the processes that lead to cell death following reperfusion, in both necrotic and apoptotic forms of cell death, and so are potential targets for protective interventions. In this review, we consider several aspect of mitochondrial function that we believe to be possible targets for myocardial protection; namely, roles of the mitochondrial ion channels in the heart with particular emphasis on cardioprotection against ischemia/reperfusion injury, mitochondrial Ca2+ transport, the permeability transition pore, and improved mitochondrial substrate supply. These protective processes are activated by signaling pathways, which converge on mitochondria; these pathways can also be stimulated by pharmacological treatments like some anesthetics with cardioprotective effects. Finally, we describe how improved understanding of the aspects of mitochondrial function may lead to better protective strategies in the future.
Filiaciones:
Departamento de Farmacología, Mexico
Departamento de Biomedicina Cardiovascular, Mexico
Departamento de Fisiología, Mexico
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