Role of Metal Cations of Copper, Iron, and Aluminum and Multifunctional Ligands in Alzheimer’s Disease: Experimental and Computational Insights
Por:
Puentes-Díaz N., Chaparro D., Morales-Morales D., Flores-Gaspar A., Alí-Torres J.
Publicada:
1 ene 2023
Resumen:
Alzheimer’s disease (AD) is the most common form of dementia, affecting millions of people around the world. Even though the causes of AD are not completely understood due to its multifactorial nature, some neuropathological hallmarks of its development have been related to the high concentration of some metal cations. These roles include the participation of these metal cations in the production of reactive oxygen species, which have been involved in neuronal damage. In order to avoid the increment in the oxidative stress, multifunctional ligands used to coordinate these metal cations have been proposed as a possible treatment to AD. In this review, we present the recent advances in experimental and computational works aiming to understand the role of two redox active and essential transition-metal cations (Cu and Fe) and one nonbiological metal (Al) and the recent proposals on the development of multifunctional ligands to stop or revert the damaging effects promoted by these metal cations. © 2023 The Authors. Published by American Chemical Society.
Filiaciones:
Puentes-Díaz N.:
Departamento de Química, Universidad Nacional de Colombia-Sede Bogotá, Bogotá, 11301, Colombia
Chaparro D.:
Departamento de Química, Universidad Nacional de Colombia-Sede Bogotá, Bogotá, 11301, Colombia
Departamento de Química, Universidad Militar Nueva Granada, Cajicá, 250240, Colombia
Morales-Morales D.:
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, 04510, Mexico
Flores-Gaspar A.:
Departamento de Química, Universidad Militar Nueva Granada, Cajicá, 250240, Colombia
Alí-Torres J.:
Departamento de Química, Universidad Nacional de Colombia-Sede Bogotá, Bogotá, 11301, Colombia
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