Emergence and widespread circulation of a recombinant SARS-CoV-2 lineage in North America
Por:
Gutierrez B., Castelán Sánchez H.G., Candido D.D.S., Jackson B., Fleishon S., Houzet R., Ruis C., Delaye L., Faria N.R., Rambaut A., Pybus O.G., Escalera-Zamudio M.
Publicada:
1 ene 2022
Resumen:
Although recombination is a feature of coronavirus evolution, previously detected recombinant lineages of SARS-CoV-2 have shown limited circulation thus far. Here, we present a detailed phylogenetic analysis of four SARS-CoV-2 lineages to investigate the possibility of virus recombination among them. Our analyses reveal well-supported phylogenetic differences between the Orf1ab region encoding viral non-structural proteins and the rest of the genome, including Spike (S) protein and remaining reading frames. By accounting for several deletions in NSP6, Orf3a, and S, we conclude that the B.1.628 major cluster, now designated as lineage XB, originated from a recombination event between viruses of B.1.631 and B.1.634 lineages. This scenario is supported by the spatiotemporal distribution of these lineages across the USA and Mexico during 2021, suggesting that the recombination event originated in this geographical region. This event raises important questions regarding the role and potential effects of recombination on SARS-CoV-2 evolution. © 2022 The Author(s)
Filiaciones:
Department of Zoology, University of Oxford, Oxford, United Kingdom
Consorcio Mexicano de Vigilancia Genómica (CoViGen-Mex), Mexico
Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito USFQ, Quito, Ecuador
Consejo Nacional de Ciencia y Tecnología, Ciudad de México, Mexico
Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
Hertzl 52, Jerusalem, Israel
10 rue de Dunkerque, Paris, 75010, France
Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
Departamento de Ingeniería Genética, Unidad Irapuato, CINVESTAV, Irapuato, Mexico
MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom
The Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, United Kingdom
Department of Pathobiology, Royal Veterinary College, London, United Kingdom
All Open Access, Hybrid Gold
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