Long-term sulforaphane-treatment restores redox homeostasis and prevents cognitive decline in middleaged female and male rats, but cannot revert previous damage in old animals
Por:
Santín-Márquez R., Hernández-Arciga U., Salas-Venegas V., Toledo-Pérez R., López-Cervantes S.P., Librado-Osorio R., Luna-López A., López-Diazguerrero N.E., Gómez-González B., Königsberg M.
Publicada:
1 ene 2022
Resumen:
Aging is a complex and detrimental process, which disrupts most organs and systems within the organisms. The nervous system is morphologically and functionally affected during normal aging, and oxidative stress has been involved in age-related damage, leading to cognitive decline and neurodegenerative processes. Sulforaphane (SFN) is a hormetin that activates the antioxidant and anti-inflammatory responses. So, we aimed to evaluate if SFN long-term treatment was able to prevent age-associated cognitive decline in adult and old female and male rats. Memory was evaluated in adult (15-month-old), and old (21-month-old) female and male Wistar rats after three months of SFN treatment. Young rats (4-month-old) were used as age controls. The antioxidant response induction, the redox state (GSH/GSSG), and oxidative damage were determined in the brain cortex (Cx) and hippocampus (Hc). Our results showed that SFN restored redox homeostasis in the Cx and Hc of adult rats, thus preventing cognitive decline in both sexes; however, the redox responses were not the same in males and females. Old rats were not able to recover their redox state as adults did, but they had a mild improvement. These results suggest that SFN mainly prevents rather than reverts neural damage; though, there might also be a range of opportunities to use hormetins like SFN, to improve redox modulation in old animals. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.
Filiaciones:
Santín-Márquez R.:
División de Ciencias Biológicas y de la Salud, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P, Mexico City, 09340, Mexico
Hernández-Arciga U.:
División de Ciencias Biológicas y de la Salud, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P, Mexico City, 09340, Mexico
Salas-Venegas V.:
División de Ciencias Biológicas y de la Salud, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P, Mexico City, 09340, Mexico
Toledo-Pérez R.:
División de Ciencias Biológicas y de la Salud, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P, Mexico City, 09340, Mexico
López-Cervantes S.P.:
División de Ciencias Biológicas y de la Salud, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P, Mexico City, 09340, Mexico
Librado-Osorio R.:
Instituto Nacional de Geriatría, SSA, Mexico City, 10200, Mexico
Luna-López A.:
Instituto Nacional de Geriatría, SSA, Mexico City, 10200, Mexico
López-Diazguerrero N.E.:
División de Ciencias Biológicas y de la Salud, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P, Mexico City, 09340, Mexico
Gómez-González B.:
Departamento de Biología de la Reproducción, DCBS, Universidad Autónoma Metropolitana Iztapalapa, Mexico City, 09340, Mexico
Königsberg M.:
División de Ciencias Biológicas y de la Salud, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P, Mexico City, 09340, Mexico
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