Chenopodium incisum Aerial Parts Extract Induces Anxiolytic-Like Effects in Mice
Por:
Cassani J., Dorantes-Barrón A.M., Mostalac-Buentello D., Adán-Ruiz A., González-Hidalgo B., Arrieta-Báez D., Estrada-Reyes R.
Publicada:
1 ene 2020
Categoría:
Pharmacology, toxicology and pharmaceutics (miscellaneous)
Resumen:
Chenopodium incisum Poir., Amaranthaceae, is employed as a remedy to alleviate susto, a culture-bound syndrome. This study evaluated the anxiolytic-like effect of a single oral dose of a hydroethanolic extract of C. incisum and two of its main constituents, pinostrobin and stigmasterol, in the elevated plus maze and hole-board test in mice. The nonspecific effects of the drugs on the ambulatory activity of mice were evaluated in the open field test. The acute toxicity of the extract was determined, and the extract composition was analyzed. The extract at 50, 100, and 200 mg/kg, as well as pinostrobin and stigmasterol (1 to 30 mg/kg), induced anxiolytic-like effects in both the elevated plus maze and in the hole-board tests, significantly increasing the exploratory behaviors. The anxiolytic actions of drugs were not associated with changes in the ambulatory activity of animals. No evidence of toxicity was observed in the animals treated with hydroethanolic extract of C. incisum. The mean lethal dose was higher than 2000 mg/kg. Chenopodium incisum elicited anxiolytic effects in mice. To the best of our knowledge, this is the first report regarding the anxiolytic effect of pinostrobin. Our results suggest that C. incisum is beneficial to patients with mood disorders. [Figure not available: see fulltext.]. © 2020, Sociedade Brasileira de Farmacognosia.
Filiaciones:
Cassani J.:
Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, Ciudad de México, Mexico
Dorantes-Barrón A.M.:
Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada Mexico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de Mexico, Mexico
Mostalac-Buentello D.:
Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada Mexico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de Mexico, Mexico
Adán-Ruiz A.:
Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada Mexico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de Mexico, Mexico
González-Hidalgo B.:
Herbario de la Universidad Autónoma Metropolitana Unidad Xochimilco, Ciudad de Mexico, Mexico
Arrieta-Báez D.:
Instituto Politécnico Nacional, Centro de Nanociencias y Micro y Nanotecnologias, Unidad Profesional Adolfo López Mateos, Ciudad de México, Mexico
Estrada-Reyes R.:
Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada Mexico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de Mexico, Mexico
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