Features of antibody responses after SARS-COV-2 infection in healthcare workers in the first wave of COVID-19 pandemic in Mexico City
Por:
Thompson-Bonilla M.D.R., León J.A., Cárdenas-Turrent M.B., Peña-Thompson A., Hanessian-De la Garza D., Zavala-Vega S., Xicohtencatl-Cortes J., Ochoa S.A., Cruz-Córdova A., Arellano-Galindo J.
Publicada:
1 ene 2022
Resumen:
Objective: To investigate the antibody response to SARS-CoV-2 and identify associated factors in frontline and second-line healthcare workers (HCWs) at a large hospital in Mexico City during the first wave of COVID-19 pandemic. Methods: This was a cross-sectional study of HCWs returning to work following mandatory isolation after recovering from COVID-19. Immunoglobulin (Ig) M and IgG antibodies elicited by SARS-CoV-2 were semiquantitatively measured using densitometric analysis of band intensities in lateral flow assay (LFA) devices. The mean pixel intensity (dots-per-inch [dpi]) of each band on the LFA was considered a measure of antibody titre. Results: Of the 111 HCWs involved in the study, antibody responses were detected in 73/111 (66%) participants. Severe COVID symptoms was associated with old age. No differences in IgM intensity were observed between men and women, but IgG intensity was significantly higher in men than in women. Second-line HCWs produced a higher IgG intensity than firstline HCWs. The IgG intensity was high in severe cases. Conclusions: For HCWs who may acquire SARS-CoV-2 infection, it is necessary to establish a routine program for detection of the virus to avoid risk of infection and spread of COVID-19. © The Author(s) 2022.
Filiaciones:
Thompson-Bonilla M.D.R.:
Laboratorio de Medicina Genómica, Hospital Regional “1° de Ocutbre”, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Mexico City, Mexico
León J.A.:
Scientific Management of KPC BiotechCA, United States
Cárdenas-Turrent M.B.:
Epidemiología, Hospital Regional “1° de Ocutbre”, ISSSTE, Mexico City, Mexico
Peña-Thompson A.:
Laboratorio de Medicina Genómica, Hospital Regional “1° de Ocutbre”, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Mexico City, Mexico
Hanessian-De la Garza D.:
Medicina Interna, Hospital Regional “1° de Ocutbre”, ISSSTE, Mexico City, Mexico
Zavala-Vega S.:
Laboratorio de Neuropatología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suarez, Mexico City, Mexico
Xicohtencatl-Cortes J.:
Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Ochoa S.A.:
Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Cruz-Córdova A.:
Laboratorio de Bacteriología Intestinal, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Arellano-Galindo J.:
Unidad de Investigación en Enfermedades Infecciosas, Laboratorio de Virología Clínica y Experimental, Hospital Infantil de México Federico Gómez, Mexico City, Mexico
Gold
|