Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence
Por:
Zavala-Tecuapetla, Cecilia, Luna-Munguia, Hiram, López-Meraz M.-L., Cuellar-Herrera, Manola
Publicada:
1 dic 2022
Resumen:
The use of Cannabis for medicinal purposes has been documented since
ancient times, where one of its principal cannabinoids extracted from
Cannabis sativa, cannabidiol (CBD), has emerged over the last few years
as a promising molecule with anti-seizure potential. Here, we present an
overview of recent literature pointing out CBD's pharmacological profile
(solubility, metabolism, drug-drug interactions, etc.,), CBD's
interactions with multiple molecular targets as well as advances in
preclinical research concerning its anti-seizure effect on both acute
seizure models and chronic models of epilepsy. We also highlight the
recent attention that has been given to other natural cannabinoids and
to synthetic derivatives of CBD as possible compounds with therapeutic
anti-seizure potential. All the scientific research reviewed here
encourages to continue to investigate the probable therapeutic efficacy
of CBD and its related compounds not only in epilepsy but also and
specially in drug-resistant epilepsy, since there is a dire need for new
and effective drugs to treat this disease.
Filiaciones:
Zavala-Tecuapetla, Cecilia:
Laboratory of Physiology of Reticular Formation, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, La Fama, Mexico City, 14269, Mexico
Luna-Munguia, Hiram:
Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus UNAM-Juriquilla, Queretaro, 76230, Mexico
López-Meraz M.-L.:
Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Luis Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa, 91190, Mexico
Cuellar-Herrera, Manola:
Epilepsy Clinic, Hospital General de México Dr. Eduardo Liceaga, Dr. Balmis 148, Doctores, Mexico City, 06720, Mexico
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