Prognostic Value of Galectin Expression in Patients with Breast Cancer: Systematic Review and Meta-Analysis
Por:
Ramos-Martínez J.C., Altamirano-Gómez G., Ramos-Martínez I., Valencia J., Hernández-Zimbrón L., Hernández-Juárez J., Echeverría-Vásquez P., Hernández-González L.L., Pérez-Campos E., Pérez-Campos Mayoral L., Ramos-Martínez E.
Publicada:
1 ene 2022
Resumen:
Galectins are a family of proteins with affinity for ß-galactosides and their expression correlates with overall survival (OS) in several cancers. However, in breast cancer their prognostic potential is unclear. In this study we performed a meta-analysis to clarify the prognostic value of galectin expression in breast cancer and to identify sources of heterogeneity. For this purpose, we performed a search of related publications in PubMed, Central-Conchrane, Web of Science database, OVID-EMBASE, Scope and EBSCOhost until November 2021.Thirteen articles were included with a total of 2700 patients. High galectin expression was found not to correlate with OS in breast cancer (HR = 1.11, 95% CI 0.93–1.31). In the case of galectin-3, correlation with OS was observed when performing subgroup analysis by cellular localization (HR = 0.59, 95% CI 0.36–0.94 for cytoplasmic and HR = 1.82, 95% CI 1.00–3.29 for cytoplasmic plus nuclear). Galectin-7 correlates with DFS/PFS/DSS (HR = 2.43; 95% CI 1.36–4.31). Finally, galectin-3 correlates with some clinicopathological features such as lymph node metastasis, estrogen receptor expression and age. In conclusion, galectin-3 correlates with OS in breast cancer when cellular localization is considered while galectin-7 correlates with DFS/PFS/DSS. The cellular localization of galectins should be as fundamental aspect to be determined in future studies. © 2021 Elsevier Inc.
Filiaciones:
Cardiology Department, Hospital General Regional Lic Ignacio Garcia Tellez IMSS, Yucatán, Mexico
Instituto de Cómputo Aplicado en Ciencias, Oaxaca, Mexico
Glycobiology, Cell Growth and Tissue Repair Research Unit (Gly-CRRET), Université Paris Est Créteil (UPEC), Créteil, France
Endocrine Research Unit, UMAE Hospital de Especialidades, Instituto Mexicano del Seguro Social, Mexico City, Mexico
Asociación para evitar la ceguera en México I.A.P, Mexico city, Mexico
CONACYT-Facultad de Odontología, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca, Mexico
Nursing Department, Instituto Oaxaqueño de Desarrollo Integral, Oaxaca, Mexico
Tecnológico Nacional de México/ ITOaxaca, Oaxaca, Mexico
Research Centre Medicine UNAM-UABJO, Facultad de Medicina, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca, Mexico
Escuela de Ciencias and Instituto de Cómputo Aplicado en Ciencias, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca, Mexico
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