Immunology of COVID-19: Current State of the Science
Por:
Vabret N., Britton G.J., Gruber C., Hegde S., Kim J., Kuksin M., Levantovsky R., Malle L., Moreira A., Park M.D., Pia L., Risson E., Saffern M., Salomé B., Esai Selvan M., Spindler M.P., Tan J., van der Heide V., Gregory J.K., Alexandropoulos K., Bhardwaj N., Brown B.D., Greenbaum B., Gümüs Z.H., Homann D., Horowitz A., Kamphorst A.O., Curotto de Lafaille M.A., Mehandru S., Merad M., Samstein R.M., Agrawal M., Aleynick M., Belabed M., Brown M., Casanova-Acebes M., Catalan J., Centa M., Charap A., Chan A., Chen S.T., Chung J., Bozkus C.C., Cody E., Cossarini F., Dalla E., Fernandez N., Grout J., Ruan D.F., Hamon P., Humblin E., Jha D., Kodysh J., Leader A., Lin M., Lindblad K., Lozano-Ojalvo D., Lubitz G., Magen A., Mahmood Z., Martinez-Delgado G., Mateus-Tique J., Meritt E., Moon C., Noel J., O'Donnell T., Ota M., Plitt T., Pothula V., Redes J., Reyes Torres I., Roberto M., Sanchez-Paulete A.R., Shang J., Schanoski A.S., Suprun M., Tran M., Vaninov N., Wilk C.M., Aguirre-Ghiso J., Bogunovic D., Cho J., Faith J., Grasset E., Heeger P., Kenigsberg E., Krammer F., Laserson U.
Publicada:
1 ene 2020
Resumen:
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection. © 2020 Elsevier Inc.The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection. © 2020 Elsevier Inc.
Filiaciones:
Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, United States
All Open Access, Bronze
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