Aspergillus-SARS-CoV-2 Coinfection: What Is Known?
Por:
Castro-Fuentes C.A., Reyes-Montes M.d.R., Frías-De-León M.G., Valencia-Ledezma, Omar E., Acosta-Altamirano, Gustavo, Duarte-Escalante, Esperanza
Publicada:
1 nov 2022
Resumen:
COVID-19-associated pulmonary aspergillosis (CAPA) has had a high
incidence. In addition, it has been associated with prolonged hospital
stays, as well as several predisposing risk factors, such as fungal
factors (nosocomial organism, the size of the conidia, and the ability
of the Aspergillus spp. of colonizing the respiratory tract),
environmental factors (remodeling in hospitals, use of air conditioning
and negative pressure in intensive care units), comorbidities, and
immunosuppressive therapies. In addition to these factors, SARS-CoV-2
per se is associated with significant dysfunction of the patient's
immune system, involving both innate and acquired immunity, with reduced
CD4+ and CD8+ T cell counts and cytokine storm. Therefore, this review
aims to identify the factors influencing the fungus so that coinfection
with SARS-CoV-2 can occur. In addition, we analyze the predisposing
factors in the fungus, host, and the immune response alteration due to
the pathogenicity of SARS-CoV-2 that causes the development of CAPA.
Filiaciones:
Castro-Fuentes C.A.:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad Universitaria, Coyoacán, Mexico City, 04510, Mexico
Reyes-Montes M.d.R.:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad Universitaria, Coyoacán, Mexico City, 04510, Mexico
Frías-De-León M.G.:
Hospital Regional de Alta Especialidad de Ixtapaluca, Carretera Federal México-Puebla Km. 34.5, Pueblo de Zoquiapan, Ixtapaluca, 56530, Mexico
Valencia-Ledezma, Omar E.:
Hospital Regional de Alta Especialidad de Ixtapaluca, Carretera Federal México-Puebla Km. 34.5, Pueblo de Zoquiapan, Ixtapaluca, 56530, Mexico
Acosta-Altamirano, Gustavo:
Hospital Regional de Alta Especialidad de Ixtapaluca, Carretera Federal México-Puebla Km. 34.5, Pueblo de Zoquiapan, Ixtapaluca, 56530, Mexico
Duarte-Escalante, Esperanza:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad Universitaria, Coyoacán, Mexico City, 04510, Mexico
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