Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer
Por:
Rojas A., Lindner C., Schneider I., Gonzàlez I., Araya H., Morales E., Gómez M., Urdaneta N., Araya P., Morales M.A.
Publicada:
1 ene 2021
Resumen:
Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial contribution of diabetes mellitus (DM) as a risk factor associated with increased cancer incidence and mortality in many human neoplasms, including gastric cancer (GC). DM is considered a systemic inflammatory disease and therefore, this inflammatory status may have profound effects on the tumor microenvironment (TME), particularly by driving many molecular mechanisms to generate a more aggressive TME. DM is an active driver in the modification of the behavior of many cell components of the TME as well as altering the mechanical properties of the extracellular matrix (ECM), leading to an increased ECM stiffening. Additionally, DM can alter many cellular signaling mechanisms and thus favoring tumor growth, invasion, and metastatic potential, as well as key elements in regulating cellular functions and cross-talks, such as the microRNAs network, the production, and cargo of exosomes, the metabolism of cell stroma and resistance to hypoxia. In the present review, we intend to highlight the mechanistic contributions of DM to the remodeling of TME in GC. ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Filiaciones:
Rojas A.:
Biomedical Research Lab., Medicine Faculty, Catholic University of Maule, Talca, 34600000, Chile
Lindner C.:
Biomedical Research Lab., Medicine Faculty, Catholic University of Maule, Talca, 34600000, Chile
Schneider I.:
Biomedical Research Lab., Medicine Faculty, Catholic University of Maule, Talca, 34600000, Chile
Gonzàlez I.:
Biomedical Research Lab., Medicine Faculty, Catholic University of Maule, Talca, 34600000, Chile
Araya H.:
Department of Clinical Sciences, Medicine Faculty, Catholic University of Maule, Talca, 34600000, Chile
Servicio de Oncología, Hospital Regional de Talca, Talca, 34600000, Chile
Morales E.:
Biomedical Research Lab., Medicine Faculty, Catholic University of Maule, Talca, 34600000, Chile
Servicio de Anatomía Patologica, Hospital Regional de Talca, Talca, 34600000, Chile
Gómez M.:
Department of Clinical Sciences, Medicine Faculty, Catholic University of Maule, Talca, 34600000, Chile
Servicio de Oncología, Hospital Regional de Talca, Talca, 34600000, Chile
Urdaneta N.:
Department of Clinical Sciences, Medicine Faculty, Catholic University of Maule, Talca, 34600000, Chile
Servicio de Oncología, Hospital Regional de Talca, Talca, 34600000, Chile
Araya P.:
Biomedical Research Lab., Medicine Faculty, Catholic University of Maule, Talca, 34600000, Chile
Morales M.A.:
Department of Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago, 8320000, Chile
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