Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol
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Schwartz G.G., Szarek M., Bittner V.A., Diaz R., Goodman S.G., Jukema J.W., Landmesser U., López-Jaramillo P., Manvelian G., Pordy R., Scemama M., Sinnaeve P.R., White H.D., Steg P.G., Bhatt D.L., Harrington R.A., Zeiher A.M., Tricoci P., Roe M.T., Mahaffey K.W., Edelberg J.M., Hanotin C., Lecorps G., Moryusef A., Sasiela W.J., Tamby J.-F., Aylward P.E., Drexel H., Sinnaeve P., Dilic M., Lopes R.D., Gotcheva N.N., Prieto J.-C., Yong H., Pecin I., Reiner Z., Ostadal P., Viigimaa M., Nieminen M.S., Danchin N., Chumburidze V., Marx N., Liberopoulos E., Montenegro Valdovinos P.C., Tse H.-F., Kiss R.G., Xavier D., Zahger D., Valgimigli M., Kimura T., Kim H.S., Kim S.-H., Erglis A., Laucevicius A., Kedev S., Yusoff K., Ramos López G.A., Alings M., Halvorsen S., Correa Flores R.M., Sy R.G., Budaj A., Morais J., Dorobantu M., Ristic A.D., Chua T., Murin J., Fras Z., Dalby A.J., Tuñón J., Asita de Silva H., Hagström E., Müller C., Chiang C.-E., Sritara P., Guneri S., Parkhomenko A., Ray K.K., Moriarty P.M., Vogel R., Chaitman B., Kelsey S.F., Olsson A.G., Rouleau J.-L., Simoons M.L., Alexander K., Meloni C., Rosenson R., Sijbrands E.J.G., Alexander J.H., Armaganijan L., Bagai A., Bahit M.C., Brennan J.M., Clifton S., DeVore A.D., Deloatch S., Dickey S., Dombrowski K., Ducrocq G., Eapen Z., Endsley P., Eppinger A., Harrison R.W., Hess C.N., Hlatky M.A., Jordan J.D., Knowles J.W., Kolls B.J., Kong D.F., Leonardi S., Lillis L., Maron D.J., Marcus J., Mathews R., Mehta R.H., Mentz R.J., Moreira H.G., Patel C.B., Pereira S.B., Perkins L., Povsic T.J., Puymirat E., Jones W.S., Shah B.R., Sherwood M.W., Stringfellow K., Sujjavanich D., Toma M., Trotter C., van Diepen S.F.P., Wilson M.D., Tze-Kay Yan A., Schiavi L.B., Garrido M., Alvarisqueta A.F., Sassone S.A., Bordonava A.P., Alves De Lima A.E., Schmidberg J.M., Duronto E.A., Caruso O.C., Novaretto L.P., Hominal M.A., Montaña O.R., Caccavo A., Gomez Vilamajo O.A., Lorenzatti A.J., Cartasegna L.R., Paterlini G.A., Mackinnon I.J., Caime G.D., Amuchastegui M., Salomone O., Codutti O.R., Jure H.O., Bono J.O.E., Hrabar A.D., Vallejos J.A., Ahuad Guerrero R.A., Novoa F., Patocchi C.A., Zaidman C.J., Giuliano M.E., Dran R.D., Vico M.L., Carnero G.S., Guzman P.N., Medrano Allende J.C., Garcia Brasca D.F., Bustamante Labarta M.H., Nani S., Blumberg E.D.S., Colombo H.R., Liberman A., Fuentealba V., Luciardi H.L., Waisman G.D., Berli M.A., Garcia Duran R.O., Cestari H.G., Luquez H.A., Giordano J.A., Saavedra S.S., Zapata G., Costamagna O., Llois S., Waites J.H., Collins N., Soward A., Hii C.L.S., Shaw J., Arstall M.A., Horowitz J., Ninio D., Rogers J.F., Colquhoun D., Oqueli Flores R.E., Roberts-Thomson P., Raffel O., Lehman S.J., Aroney C., Coverdale S.G.M., Garrahy P.J., Starmer G., Sader M., Carroll P.A., Dick R., Zweiker R., Hoppe U., Huber K., Berger R., Delle-Karth G., Frey B., Faes D., Hermans K., Pirenne B., Leone A., Hoffer E., Vrolix M.C.M., De Wolf L., Wollaert B., Castadot M., Dujardin K., Beauloye C., Vervoort G., Striekwold H., Convens C., Roosen J., Barbato E., Claeys M., Cools F., Terzic I., Barakovic F., Midzic Z., Pojskic B., Fazlibegovic E., Durak-Nalbantic A., Kulic M., Vulic D., Muslibegovic A., Goronja B., Reis G., Sousa L., Nicolau J.C., Giorgeto F.E., Silva R.P., Maia L.N., Rech R., Rossi P.R.F., Cerqueira M.J.A.G., Duda N., Kalil R., Kormann A., Abrantes J.A.M., Filho P.P., Soggia A.P., de Santos M.O.N., Neuenschwander F., Bodanese L.C., Michalaros Y.L., Eliaschewitz F.G., Vidotti M.H., Leaes P.E., Botelho R.V., Kaiser S., Fernandes Manenti E.R.F., Precoma D.B., Moura Jorge J.C., Silva P., Silveira J.A., Saporito W., Marin Neto J.A., Feitosa G.S., Ritt L.E.F., de Souza J.A., Costa F., Souza W.K.S.B., Reis H.J.L., Machado L., Aidar Ayoub J.C., Todorov G.V., Nikolov F.P., Velcheva E.S., Tzekova M.L., Benov H.O., Petranov S.L., Tumbev H.S., Shehova-Yankova N.S., Markov D.T., Raev D.H., Mollov M.N., Kichukov K.N., Ilieva-Pandeva K.A., Ivanova R., Gospodinov M., Mincheva V.M., Lazov P.V., Dimov B.I., Senaratne M., Stone J., Kornder J., Pearce S., Dion D., Savard D., Pesant Y., Pandey A., Robinson S., Gosselin G., Vizel S., Hoag G., Bourgeois R., Morisset A., Sabbah E., Sussex B., Kouz S., MacDonald P., Diaz A., Michaud N., Fell D., Leung R., Vuurmans T., Lai C., Nigro F., Davies R., Nogareda G., Vijayaraghavan R., Ducas J., Lepage S., Mehta S., Cha J., Dupuis R., Fong P., Lutchmedial S., Rodes-Cabau J., Fadlallah H., Cleveland D., Huynh T., Bata I., Hameed A., Pincetti C., Potthoff S., Prieto J.C., Acevedo M., Aguirre A., Vejar M., Yañez M., Araneda G., Fernandez M., Perez L., Varleta P., Florenzano F., Huidobro L., Raffo C.A., Olivares C., Nahuelpan L., Montecinos H., Chen J., Dong Y., Huang W., Huang S.A., Yao Z., Cui L., Lin W., Wang J., Li J., Zhang X., Zhu H., Chen D., Huang L., Dong S., Su G., Xu B., Su X., Cheng X., Lin J., Zong W., Li H., Feng Y., Xu D., Ke Y., Lin X., Zhang Z., Zheng Z., Luo Z., Chen Y., Ding C., Zhong Y., Zheng Y., Li X., Peng D., Zhao S., Li Y., Liu X., Wei M., Liu S., Yu Y., Qu B., Jiang W., Zhou Y., Zhao X., Yuan Z., Guo Y., Xu X., Shi X., Ge J., Fu G., Bai F., Fang W., Shou X., Yang X., Wang J.A., Xiang M., Sun Y., Lu Q., Zhang R., Zhu J., Xu Y., Fan Z., Li T., Wu C., Jaramillo N., Vallejo G.S., Luna Botia D.C., Lopez R.B., Molina De Salazar D.I., Cadena Bonfanti A.J., Aroca C.C., Higuera J.D., Blanquicett M., Barrera Silva S.I., Garcia Lozada H.J., Coronel Arroyo J.A., Accini Mendoza J.L., Fernandez Ruiz R.L., Quintero Ossa A.M., Manzur Jatin F.G., Herazo A.S., Parada J.C., Arambula R.S., Urina Triana M.A., Fernandez Trujillo A.M., Strozzi M., Car S., Jeric M., Milicic D., Bencic M.L., Pintaric H., Prvulovic Ð., Šikic J., Peršic V., Mileta D., Štambuk K., Babic Z., Tomulic V., Lukenda J., Mejic-Krstulovic S., Starcevic B., Spinar J., Horak D., Velicka Z., Stasek J., Alan D., Machova V., Linhart A., Novotny V., Kaucak V., Rokyta R., Naplava R., Coufal Z., Adamkova V., Podpera I., Zizka J., Motovska Z., Marusincova I., Svab P., Heinc P., Kuchar J., Povolny P., Matuska J., Poulsen S.H., Raungaard B., Clemmensen P., Bang L.E., May O., Bøttcher M., Hove J.D., Frost L., Gislason G., Larsen J., Johansen P.B., Hald F., Johansen P., Jeppesen J., Nielsen T., Kristensen K.S., Walichiewicz P.M., Lomholdt J.D., Klausen I.C., Nielsen P.K., Davidsen F., Videbaek L., Soots M., Vahula V., Hedman A., Soopõld Ü., Märtsin K., Jurgenson T., Kristjan A., Huikuri H., Pierre Coste J.A., Ferrari E., Morel O., Montalescot G., Machecourt J., Barone-Rochette G., Mansourati J., Cottin Y., Leclercq F., Belhassane A., Delarche N., Boccara F., Paganelli F., Clerc J., Schiele F., Aboyans V., Probst V., Berland J., Lefèvre T., Citron B., Khintibidze I., Shaburishvili T., Pagava Z., Ghlonti R., Lominadze Z., Khabeishvili G., Hemetsberger R., Edward K., Rauch-Kröhnert U., Stratmann M., Appel K.-F., Schmidt E., Omran H., Stellbrink C., Dorsel T., Lianopoulos E., Vöhringer H.F., Marx R., Zirlik A., Schellenberg D., Heitzer T., Laufs U., Werner C., Gielen S., Nuding S., Winkelmann B., Behrens S., Sydow K., Karakas M., Simonis G., Muenzel T., Werner N., Leggewie S., Böcker D., Braun-Dullaeus R., Toursarkissian N., Jeserich M., Weißbrodt M., Schaeufele T., Weil J., Völler H., Waltenberger J., Natour M., Schmitt S., Müller-Wieland D., Steiner S., Heidenreich L., Offers E., Gremmler U., Killat H., Rieker W., Patsilinakos S., Kartalis A., Manolis A., Sionis D., Chachalis G., Skoumas I., Athyros V., Vardas P., Parthenakis F., Lekakis J., Hatzitolios A., Fausto Ovando S.R., Arango Benecke J.L., Rodriguez De Leon E.R., Yan B.P.Y., Siu D.C.W., Turi T., Merkely B., Ungi I., Lupkovics G., Nagy L., Katona A., Édes I., Müller G., Horvath I., Kapin T., Szigeti Z., Faluközy J., Kumbla M., Sandhu M., Annam S., Proddutur N.R., Regella R., Premchand R.K., Mahajan A., Pawar S., Abhyanakar A.D., Kerkar P., Govinda R.A., Oomman A., Sinha D., Patil S.N., Kahali D., Sawhney J., Joshi A.B., Chaudhary S., Harkut P., Guha S., Porwal S., Jujjuru S., Pothineni R.B., Monteiro M.R., Iyengar S.S., Grewal J.S., Chopda M., Fulwani M.C., Patange A., Sachin P., Chopra V.K., Goyal N.K., Shinde R., Manakshe G.V., Patki N., Sethi S., Munusamy V., Sunil Thanvi S.K., Adhyapak S., Patil C., Pandurangi U., Mathur R., Gupta J., Kalashetti S., Bhagwat A., Raghuraman B., Yerra S.K., Bhansali P., Borse R., Rahul P., Das S., Kumar V., Abdullakutty J., Saathe S., Palimkar P., Abdullkutty J., Sathe S., Atar S., Shechter M., Mosseri M., Arbel Y., Ehud C., Ofer H., Lotan C., Rosenschein U., Katz A., Henkin Y., Francis A., Klutstein M., Nikolsky E., Zukermann R., Turgeman Y., Halabi M., Marmor A., Kornowski R., Jonas M., Amir O., Hasin Y., Rozenman Y., Fuchs S., Zvi V., Hussein O., Gavish D., Vered Z., Caraco Y., Elias M., Tov N., Wolfovitz E., Lishner M., Elias N., Piovaccari G., De Pellegrin A., Garbelotto R., Guardigli G., Marco V., Licciardello G., Auguadro C., Scalise F., Cuccia C., Salvioni A., Musumeci G., Senni M., Calabrò P., Novo S., Faggiano P., Metra M., De Cesare N.B., Berti S., Cavallini C., Puccioni E., Galvani M., Tespili M., Piatti P., Palvarini M., De Luca G., Violini R., De Leo A., Olivari Z., Filardi P.P., Ferratini M., Racca V., Dai K., Shimatani Y., Kamiya H., Ando K., Takeda Y., Morino Y., Hata Y., Kimura K., Kishi K., Michishita I., Uehara H., Higashikata T., Hirayama A., Hirooka K., Doi Y., Sakagami S., Taguchi S., Koike A., Fujinaga H., Koba S., Kozuma K., Kawasaki T., Ono Y., Shimizu M., Katsuda Y., Wada A., Shinke T., Ako J., Fujii K., Takahashi T., Sakamoto T., Nakao K., Furukawa Y., Sugino H., Tamura R., Mano T., Uematsu M., Utsu N., Ito K., Haraguchi T., Sato K., Ueda Y., Nishibe A., Fujimoto K., Masutani M., Yoon J.H., Kim H.-L., Park H.S., Chae I.-H., Kim M.H., Jeong M.H., Rha S., Kim C., Kim H.Y., Hong T., Tahk S.-J., Kim Y., Busmane A., Pontaga N., Strelnieks A., Mintale I., Sime I., Petrulioniene Z., Kavaliauskiene R., Jurgaitiene R., Sakalyte G., Slapikas R., Norkiene S., Misonis N., Kibarskis A., Kubilius R., Bojovski S., Lozance N., Kjovkaroski A., Doncovska S., Ong T.K., Kasim S., Maskon O., Kandasamy B., Liew H.B., Izani Wan Mohamed W.M., Castillo A.G., Calvillo J.C., Campos P.F., Núñez Fragoso J.C., Bayram Llamas E.A., Alcocer Gamba M.A., Madrigal J.C., González Salas L.G., Rosas E.L., González Díaz B., Salcido Vázquez E., Nacoud Ackar A., Antonio Llamas Esperón G., Rodolfo Martínez Sánchez C., Guerrero De Leon M., Suarez Otero R., Fanghänel Salmón G., Pérez Ríos J.A., Garza Ruíz J.A., Breedveld R.W., Feenema-Aardema M., Borger-Van Der Burg A., Hoogslag P.A.M., Suryapranata H., Oomen A., Van Haelst P., Feenema-Aradema M., Wiersma J.J., Basart D., Van Der Wal R.M.A., Zwart P., Monraats P., Van Kesteren H., Karalis I., Jukema J., Verdel G.J.E., Brueren B.R.G., Troquay R.P., Viergever E.P., Al-Windy N.Y.Y., Bartels G.L., Cornel J.H., Hermans W.R.M., Herrman J.P.R., Bos R.J., Groutars R.G.E.J., Van Der Zwaan C.C., Kaplan R., Lionarons R., Ronner E., Groenemeijer B.E., Bronzwaer P.N.A., Liem A.A.H., Rensing B.J.W.M., Bokern M.J.J.A., Nijmeijer R., Hersbach F.M.R.J., Willems F.F., Gosselink A.T.M., Rasoul S., Elliott J., Wilkins G., Fisher R., Scott D., Hart H., Stewart R., Harding S., Ternouth I., Fisher N., Wilson S., Aitken D., Anscombe R., Davidson L., Tomala T., Nygård O., Sparby J.A., Andersen K., Gullestad L., Jortveit J., Munk P.S., Singsaas E.G., Hurtig U., Calderon Ticona J.R., Durand Velasquez J.R., Negron Miguel S.A., Sanabria Perez E.S., Carrion Chambilla J.M., Chavez Ayala C.A., Castillo Leon R.P., Vargas Gonzales R.J., Hernandez Zuniga J.D., Camacho Cosavalente L.A., Bravo Mannucci J.E., Landeo J.H., Llerena Navarro N.C., Roldan Concha Y.M., Rodriguez Chavez V.E., Anchante Hernandez H.A., Zea Nunez C.A., Ramos W.M., Ferrolino A., Sy R.A.G., Tirador L., Matiga G., Coching R.M., Bernan A., Rogelio G., Morales D.D., Tan E., Sulit D.J., Wlodarczak A., Jaworska K., Skonieczny G., Pawlowicz L., Wojewoda P., Busz-Papiez B., Bednarski J., Goch A., Staneta P., Dulak E., Saminski K., Krasowski W., Sudnik W., Zurakowski A., Skorski M., Lysek R., Miklaszewicz B., Kubica J., Lipko J.A., Kostarska-Srokosz E., Piepiorka M., Drzewiecka A., Sciborski R., Stasiewski A., Blicharski T., Bystryk L., Szpajer M., Korol M., Czerski T., Mirek-Bryniarska E., Gniot J., Lubinski A., Gorny J., Franek E., Raczak G., Szwed H., Monteiro P., Bastos J.M., Pereira H.H., Martins D., Seixo F., Mendonça C., Botelho A., Caetano F., Minescu B., Istratoaie O., Tesloianu D.N., Cristian G., Dumitrescu S., Podoleanu C.G.C., Constantinescu M.C.A., Bengus C.M., Militaru C., Rosu D., Parepa I.R., Matei A.V., Alexandru T.M., Malis M., Coman I., Stanescu-Cioranu R., Dimulescu D., Shvarts Y., Orlikova O., Kobalava Z., Barbarash O.L., Markov V., Lyamina N., Gordienko A., Zrazhevsky K., Vishnevsky A.Y., Gurevich V., Stryuk R., Lomakin N.V., Bokarev I., Khlevchuk T., Shalaev S., Khaisheva L., Chizhov P., Viktorova I., Osokina N., Shchekotov V., Akatova E., Chumakova G., Libov I., Voevoda M.I., Tretyakova T.V., Baranov E., Shustov S., Yakushin S., Gordeev I., Khasanov N., Reshetko O., Sotnikova T., Molchanova O., Nikolaev K., Gapon L., Baranova E., Shogenov Z., Kosmachova E., Karpov Y., Povzun A., Egorova L., Tyrenko V.V., Ivanov I.G., Ilya M., Kanorsky S., Simic D., Ivanovic N., Davidovic G., Tasic N., Asanin M.R., Stojic S., Apostolovic S.R., Ilic S., Tosic B.P., Stankovic A., Arandjelovic A., Radovanovic S., Todic B., Balinovac J., Dincic D.V., Seferovic P., Karadzic A., Dodic S., Dimkovic S., Jakimov T., Poh K.-K., Ong H.Y., I-Shing J.T., Micko K., Nociar J., Pella D., Fulop P., Hranai M., Palka J., Mazur J., Majercák I., Dzupina A., Fazekas F., Gonsorcik J., Bugan V., Selecky J., Kamensky G., Strbova J., Smik R., Dukat A., Olexa P., Žuran I., Poklukar J., Šuligoj N.C., Cevc M., Cyster H.P., Ranjith N., Corbett C., Bayat J., Makotoko E.M., du Toit Theron H., Kapp I.E., de V Basson M.M., Lottering H., Van Aswegen D., Van Zyl L.J., Sebastian P.J., Pillay T., Saaiman J.A., Commerford P.J., Cassimjee S., Riaz G., Ebrahim I.O., Sarvan M., Mynhardt J.H., Reuter H., Moodley R., Vida M., Cequier Fillat A.R., Peris V.B., Jimenez F.F., Marín F., Cruz Fernández J.M., Hidalgo Urbano R.J., Gil-Extremera B., Toledo P., Diz F.W., Garcia-Dorado D., Iñiguez A., Fernández J.T., Gonzalez-Juanatey J.R., Portales J.F., Murillo F.C., Pericas L.M., Zamorano J.L., De Mora Martin M., Cortada J.B., Alonso Martin J.J., Serrano Antolin J.M., De Berrazueta Fernández J.R., Vázquez de Prada J.A., Díaz Fernández J.F., García Lledó J.A., Sales J.C., Rodriguez J.B., Tragant G.G., Benedicto A., Gonzalez-Juanatey C., Potau M.C., Perez I.P., De La Tassa C.M., Loma-Osorio Rincon P., Recena J.B., Escudier J.M., Payeras A.C., Orcajo N.A., Valdivielso P., Constantine G., Haniffa R., Tissera N., Amarasekera S., Ponnamperuma C., Fernando N., Fernando K., Jayawardena J., Wijeyasingam S., Ranasinghe G., Ekanayaka R., Mendis S., Senaratne V., Mayurathan G., Rajapaksha A., Sirisena T., Herath J.I., Amarasena N., Berglund S., Rasmanis G., Vedin O., Witt N., Mourtzinis G., Nicol P., Hansen O., Romeo S., Jensen S.A., Torstensson I., Ahremark U., Sundelin T., Moccetti T., Mach F., Binde R., Gämperli O., Tsai W.-C., Ueng K.-C., Lai W.-T., Liu M.-E., Hwang J.-J., Yin W.-H., Hsieh I.-C., Hsieh M.-J., Lin W.H., Kuo J.-Y., Huang T.-Y., Fang C.-Y., Kaewsuwanna P., Soonfuang W., Jintapakorn W., Sukonthasarn A., Wongpraparut N., Sastravaha K., Sansanayudh N., Kehasukcharoen W., Piyayotai D., Chotnoparatpat P., Camsari A., Kultursay H., Mutlu B., Ersanli M., Demirtas M., Kirma C., Ural E., Koldas L., Karpenko O., Prokhorov A., Vakaluyk I., Myshanych H., Reshotko D., Batushkin V., Rudenko L., Kovalskyi I., Kushnir M., Tseluyko V., Mostovoy Y., Stanislavchuk M., Kyiak Y., Karpenko Y., Malynovsky Y., Klantsa A., Kutniy O., Amosova E., Tashchuk V., Leshchuk O., Rishko M., Kopytsya M., Yagensky A., Vatutin M., Bagriy A., Barna O.M., Ushakov O., Dzyak G., Goloborodko B., Rudenko A., Zheleznyy V., Trevelyan J., Zaman A., Moriarty A., Aggarwal R.K., Clifford P., Wong Y.-K., Iqbal S.M.R., Subkovas E., Braganza D., Sarkar D., Storey R., Griffiths H., Mcclure S., Muthusamy R., Smith S., Kurian J., Levy T., Barr C., Kadr H., Gerber R., Simaitis A., Soran H., Mathur A., Brodison A., Ayaz M., Cheema M., Oliver R., Thackray S., Mudawi T., Rahman G., Sultan A., Reynolds T., Sharman D., david Sprigings, Butler R., Wilkinson P., Lip G.Y.H., Halcox J., Gallagher S., Ossei-Gerning N., Vardi G., Baldari D., Brabham D., Treasure C., II, Dahl C., Palmer B., Wiseman A., Khan A., Puri S., Mohart A.E., Ince C., Flores E., Wright S., Cheng S.-C., Rosenberg M., Rogers W., Kosinski E., Forgosh L., Waltman J., Khan M., Shoukfeh M., Dagher G., Cambier P., Lieber I., Kumar P., East C., Krichmar P., Hasan M., White L., Knickelbine T., Haldis T., Gillespie E., Amidon T., Suh D., Arif I., Abdallah M., Akhter F., Carlson E., D'Urso M., El-Ahdab F., Nelson W., Moriarty K., Cohen S., Carter L., Doty D., Sabatino K., Haddad T., Malik A., Rao S., Mulkay A., Jovin I., Klancke K., Malhotra V., Devarapalli S.K., Koren M., Chandna H., Dodds G., Goraya T., Bengston J., Janik M., Moran J., Sumner A., Kobayashi J., Davis W., Yazdani S., Pasquini J., Thakkar M., Vedere A., Leimbach W., Rider J., fenton S., Singh N., Shah A.V., Janosik D., Pepine C., Berman B., Gelormini J., Daniels C., Richard K., Keating F., Kondo N.I., Shetty S., Levite H., Waider W., Takata T., Abu-Fadel M., Shah V., Aggarwal R., Izzo M., Kumar A., Hattler B., Do R., Link C., Bortnick A., Kinzfogl G., III, Ghitis A., Larry J., Teufel E., Kuhlman P., Mclaurin B., Zhang W., Thew S., Abbas J., White M., Islam O., Subherwal S., Ranadive N., Vakili B., Gring C., Henderson D., Schuchard T., Farhat N., Kline G., Mahal S., Whitaker J., Speirs S., Andersen R., Daboul N., Horwitz P., Zahr F., Ponce G., Jafar Z., Mcgarvey J., Panchal V., Voyce S., Blok T., Sheldon W., Azizad M.M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G.T., Massey C., Wattanakit K., O'Donnell P.J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Lee K., Marais H.J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A.S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W.J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F.M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P.S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker; John M Gilbert B., Chalavarya G., Eaton C., Schmedtje J.F., Jr., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Harris B., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Brégeault M.-F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Veronique Agnetti, Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Loizeau V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Colhoun H.M., Dempsey M.A., McClanahan M.A.
Publicada:
1 ene 2021
Categoría:
Cardiology and cardiovascular medicine
Resumen:
Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains =70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was <70 mg/dL (median 69.4 mg/dL; interquartile range: 64.3-74.0 mg/dL); in 14,573 patients (77.0%), both determinations were =70 mg/dL (median 94.0 mg/dL; interquartile range: 83.2-111.0 mg/dL). Results: In the lower LDL-C subgroup, MACE rates were 4.2 and 3.1 per 100 patient-years among placebo-treated patients with baseline lipoprotein(a) greater than or less than or equal to the median (13.7 mg/dL). Corresponding adjusted treatment hazard ratios were 0.68 (95% confidence interval [CI]: 0.52-0.90) and 1.11 (95% CI: 0.83-1.49), with treatment-lipoprotein(a) interaction on MACE (Pinteraction = 0.017). In the higher LDL-C subgroup, MACE rates were 4.7 and 3.8 per 100 patient-years among placebo-treated patients with lipoprotein(a) >13.7 mg/dL or =13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402) © 2021 The Authors
Filiaciones:
Schwartz G.G.:
Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, United States
Szarek M.:
Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, United States
State University of New York, Downstate School of Public Health, Brooklyn, NY, United States
CPC Clinical Research and Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, United States
Bittner V.A.:
Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States
Diaz R.:
Estudios Cardiologicos Latinoamerica, Instituto Cardiovascular de Rosario, Rosario, Argentina
Goodman S.G.:
Canadian VIGOUR Centre, University of Alberta, Edmonton, AB, Canada
St Michael's Hospital, University of Toronto, Toronto, ON, Canada
Jukema J.W.:
Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands
Netherlands Heart Institute, Utrecht, Netherlands
Landmesser U.:
Department of Cardiology, Charité Universitätsmedizin Berlin, Berlin, Germany
López-Jaramillo P.:
Masira Research Institute, Medical School (UDES), Bucaramanga, Colombia
Manvelian G.:
Regeneron Pharmaceuticals, Tarrytown, NY, United States
Pordy R.:
Regeneron Pharmaceuticals, Tarrytown, NY, United States
Scemama M.:
Sanofi, Paris, France
Sinnaeve P.R.:
Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium
White H.D.:
Green Lane Cardiovascular Services, Auckland City Hospital, Auckland, New Zealand
Steg P.G.:
Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, French Alliance for Cardiovascular Trials, and INSERM U1148, Paris, France
Imperial College, Royal Brompton Hospital, London, United Kingdom
Sinnaeve P.:
Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium
Jukema J.:
Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands
Netherlands Heart Institute, Utrecht, Netherlands
All Open Access, Hybrid Gold
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