TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator
Por:
Franco-Juarez, Berenice, Coronel-Cruz, Cristina, Hernandez-Ochoa, Beatriz, Gomez-Manzo, Saul, Cardenas-Rodriguez, Noemi, Arreguin-Espinosa, Roberto, Bandala, Cindy, Miguel Canseco-Avila, Luis, Ortega-Cuellar, Daniel
Publicada:
1 oct 2022
Categoría:
Biochemistry, genetics and molecular biology (miscellaneous)
Resumen:
Transcription factor EB (TFEB) is considered the master transcriptional
regulator of autophagy and lysosomal biogenesis, which regulates target
gene expression through binding to CLEAR motifs. TFEB dysregulation has
been linked to the development of numerous pathological conditions;
however, several other lines of evidence show that TFEB might be a point
of convergence of diverse signaling pathways and might therefore
modulate other important biological processes such as cellular
senescence, DNA repair, ER stress, carbohydrates, and lipid metabolism
and WNT signaling-related processes. The regulation of TFEB occurs
predominantly at the post-translational level, including
phosphorylation, acetylation, SUMOylating, PARsylation, and
glycosylation. It is noteworthy that TFEB activation is
context-dependent; therefore, its regulation is subjected to coordinated
mechanisms that respond not only to nutrient fluctuations but also to
stress cell programs to ensure proper cell homeostasis and organismal
health. In this review, we provide updated insights into novel
post-translational modifications that regulate TFEB activity and give an
overview of TFEB beyond its widely known role in autophagy and the
lysosomal pathway, thus opening the possibility of considering TFEB as a
potential therapeutic target.
Filiaciones:
Franco-Juarez, Berenice:
Univ Nacl Autonoma Mexico, Dept Neurodesarrollo & Fisiol, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Coronel-Cruz, Cristina:
Univ Nacl Autonoma Mexico, Dept Biol Celular & Tisular, Fac Med, Mexico City 04510, DF, Mexico
Hernandez-Ochoa, Beatriz:
Secretaria Salud Mexico, Lab Inmunoquim, Hosp Infantil Mexico Federico Gomez, Mexico City 06720, DF, Mexico
Gomez-Manzo, Saul:
Secretaria Salud Mexico, Lab Bioquim Genet, Inst Nacl Pediat, Mexico City 04530, DF, Mexico
Cardenas-Rodriguez, Noemi:
Secretaria Salud Mexico, Lab Neurociencias, Inst Nacl Pediat, Mexico City 04530, DF, Mexico
Inst Politecn Nacl, Escuela Super Med, Mexico City 11340, DF, Mexico
Arreguin-Espinosa, Roberto:
Univ Nacl Autonoma Mexico, Inst Quim, Dept Quim Biomacromol, Mexico City 04510, DF, Mexico
Bandala, Cindy:
Inst Politecn Nacl, Escuela Super Med, Mexico City 11340, DF, Mexico
SSa, Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Neurociencias Basicas, Mexico City 14389, DF, Mexico
Miguel Canseco-Avila, Luis:
Univ Autonoma Chiapas, Fac Ciencias Quim, Campus 4, Tapachula Chiapas 30700, Mexico
Ortega-Cuellar, Daniel:
Secretaria Salud Mexico, Lab Nutr Expt, Inst Nacl Pediat, Mexico City 04530, DF, Mexico
gold, All Open Access, Gold
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