Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System
Por:
Rodriguez-Morales, Jahir, Guartazaca-Guerrero, Sebastian, Rizo-Tellez, Salma A., Viurcos-Sanabria, Rebeca, Valeria Barron, Eira, Hernandez-Valencia, Aldo F., Nava, Porfirio, Escobedo, Galileo, Damian Carrillo-Ruiz, Jose, Mendez-Garcia, Lucia A.
Publicada:
1 ago 2022
Resumen:
Transsynaptic transport is the most accepted proposal to explain the
SARS-CoV-2 infection of the CNS. Nevertheless, emerging evidence shows
that neurons do not express the SARS-CoV-2 receptor ACE2, which
highlights the importance of the blood-brain barrier (BBB) in preventing
virus entry to the brain. In this study, we examine the presence of
SARS-CoV-2 messenger ribonucleic acid (mRNA) and the cytokine profile in
cerebrospinal fluids (CSF) from two patients with a brain tumor and
COVID-19. To determine the BBB damage, we evaluate the Q- albumin index,
which is an indirect parameter to assess the permeability of this
structure. The Q-albumin index of the patient with an intraventricular
brain tumor suggests that the BBB is undamaged, preventing the passage
of SARS-CoV-2 and pro-inflammatory molecules. The development of brain
tumors that disrupt the BBB (measured by the Q-albumin index), in this
case, a petroclival meningioma (Case 1), allows the free passage of the
SARS-CoV-2 virus and probably lets the free transit of pro-inflammatory
molecules to the CNS, which leads to a possible activation of the
microglia (astrogliosis) and an exacerbated immune response represented
by IL-13, IFN-gamma, and IL-2 trying to inhibit both the infection and
the carcinogenic process.
Filiaciones:
Univ Nacl Autonoma Mexico, Fac Med, Neurosurg Specialty, Mexico City 04510, DF, Mexico
Gen Hosp Mexico Dr Eduardo Liceaga, Neurol & Neurosurg Unit, Mexico City 06720, DF, Mexico
Gen Hosp Mexico Dr Eduardo Liceaga, Res Div, Lab Immunometab, Mexico City 06720, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, PECEM, Mexico City 04510, DF, Mexico
Gen Hosp Mexico Dr Eduardo Liceaga, Genom Med, Mexico City 06720, DF, Mexico
Gen Hosp Mexico, Unit Stereotact & Funct Neurosurg, Mexico City 06720, DF, Mexico
CINVESTAV IPN, Dept Physiol, Mexico City 07360, DF, Mexico
CINVESTAV IPN, Dept Biophys, Mexico City 07360, DF, Mexico
CINVESTAV IPN, Dept Neurosci, Mexico City 07360, DF, Mexico
Gen Hosp Mexico, Direct Res, Mexico City 06720, DF, Mexico
Anahuac Univ, Fac Hlth Sci, Mexico City 52786, DF, Mexico
Green Published, gold, All Open Access, Gold, Green
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