Hepatic mir-122-3p, mir-140-5p and mir-148b-5p expressions are correlated with serum levels in MAFLD
Por:
Lopez-Sanchez, Guillermo N., Montalvo-Jave, Eduardo, Dominguez-Perez, Mayra, Antuna-Puente, Barbara, Beltran-Anaya, Fredy O., Hidalgo-Miranda, Alfredo, Chavez-Tapia, Norberto C., Uribe, Misael, Nuño- Lámbarri N.
Publicada:
1 nov 2022
Resumen:
Introduction and objectives: Metabolic-associated fatty liver disease
(MAFLD) is defined by steatosis in more than 5% of hepatocytes without
other liver diseases. Patients with this disease can progress to
multiple stages like liver fibrosis, cirrhosis, and hepatocellular
carcinoma. miRNAs are single-stranded molecules that regu-late metabolic
homeostasis; their differential expression postulates them as potential
circulating biomarkers for MAFLD. Previous research reported that
hsa-miR-140-5p, hsa-miR-148-5p, and hsa-miR-122-3p have a differential
expression in patients with MAFLD. This study aimed to investigate the
correlation between liver hsa-miR-140-5p, hsa-miR-148-5p, and
hsa-miR-122-3p and serum biomarkers CK-18, APOB, IL-6, IL-32, and TNF-a
in patients with MAFLD compared with control patients.Materials and
methods: A cross-sectional study was carried out with 16 patients of
both sexes, aged between 18-60 years, to determine the association
between the levels of hsa-miR-140-5p, hsa-miR-148-5p, and hsa-miR-122-3p
with MAFLD in liver biopsies of patients who underwent laparoscopic
cholecystectomy.Results: Twelve patients presented MAFLD, four without
hepatic steatosis. Circulating levels of CK-18 showed a significant
difference in patients with MAFLD, and a strong correlation was found
between hsa-miR-122-3p, hsa-miR-140-5p, and hsa-miR-148b-5p versus the
CAP value.Conclusion: There is a correlation between elevated tissue
expression of hsa-miR-122-3p, hsa-miR-140-5p, and hsa-miR-148b-3p with
plasma levels of CK-18 in patients with simple steatosis compared with
patients without the disease.(c) 2022 Fundacion Clinica Medica Sur, A.C.
Published by Elsevier Espana, S.L.U. This is an open access article
under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/)
Filiaciones:
Lopez-Sanchez, Guillermo N.:
Traslational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico
Med Sur Clin & Fdn, Traslat Res Unit, Mexico City, DF, Mexico
Montalvo-Jave, Eduardo:
Department of Surgery, Faculty of Medicine, The National Autonomous University of Mexico (UNAM), Mexico City, Mexico
Hepato Pancreato and Biliary Clinic, Department of General Surgery, “Hospital General de Mexico”, Dr. Eduardo Liceaga, Mexico City, Mexico
Obesity and Digestive Diseases Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico
Natl Autonomous Univ Mexico UNAM, Fac Med, Dept Surg, Mexico City, DF, Mexico
Hosp Gen Mexico Dr Eduardo Liceaga, Dept Gen Surg, Hepato Pancreato & Biliary Clin, Mexico City, DF, Mexico
Med Sur Clin & Fdn, Obes & Digest Dis Unit, Mexico City, DF, Mexico
Dominguez-Perez, Mayra:
Genomics of Cardiovascular Diseases Laboratory, National Institute of Genomic Medicine, Mexico City, Mexico
Natl Inst Genom Med, Genom Cardiovasc Dis Lab, Mexico City, DF, Mexico
Antuna-Puente, Barbara:
Infection Disease Division, Department of Medicine, Queen's University, Kingston, ON, Canada
Queens Univ, Dept Med, Infect Dis Div, Kingston, ON, Canada
Beltran-Anaya, Fredy O.:
Virology Laboratory, Faculty of Chemical Biological Sciences, UAGro, Lázaro Cárdenas
UAGro Lazaro Cardenas, Fac Chem Biol Sci, Virol Lab, Mexico City, DF, Mexico
Hidalgo-Miranda, Alfredo:
Genomics of Cancer Diseases Laboratory, National Institute of Genomic Medicine., Mexico City, Mexico
Natl Inst Genom Med, Genom Canc Dis Lab, Mexico City, DF, Mexico
Chavez-Tapia, Norberto C.:
Traslational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico
Obesity and Digestive Diseases Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico
Med Sur Clin & Fdn, Traslat Res Unit, Mexico City, DF, Mexico
Med Sur Clin & Fdn, Obes & Digest Dis Unit, Mexico City, DF, Mexico
Uribe, Misael:
Obesity and Digestive Diseases Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico
Med Sur Clin & Fdn, Obes & Digest Dis Unit, Mexico City, DF, Mexico
Nuño- Lámbarri N.:
Traslational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico
hybrid, All Open Access; Gold
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