Ivermectin: A Controversial Focal Point during the COVID-19 Pandemic
Por:
Castillejos-Lopez, Manuel, Torres-Espindola, Luz Maria, Huerta-Cruz, Juan Carlos, Flores-Soto, Edgar, Romero-Martinez, Bianca S., Velazquez-Cruz, Rafael, Higuera-Iglesias, Anjarath, Camarena, Angel, Torres-Soria, Ana Karen, Salinas-Lara, Citlaltepetl, Fernandez-Plata, Rosario, Alvarado-Vasquez, Noe, Solis-Chagoyan, Hector, Ruiz, Victor, Aquino-Galvez, Arnoldo
Publicada:
1 sep 2022
Resumen:
The SARS-CoV-2 pandemic has confirmed the apocalyptic predictions that
virologists have been making for several decades. The challenge the
world is facing is that of trying to find a possible treatment, and a
viable and expedient option for addressing this challenge is the
repurposing of drugs. However, in some cases, although these drugs are
approved for use in humans, the mechanisms of action involved are
unknown. In this sense, to justify its therapeutic application to a new
disease, it is ideal, but not necessary, to know the basic mechanisms of
action involved in a drug's biological effects. This review compiled the
available information regarding the various effects attributed to
Ivermectin. The controversy over its use for the treatment of COVID-19
is demonstrated by this report that considers the proposal unfeasible
because the therapeutic doses proposed to achieve this effect cannot be
achieved. However, due to the urgent need to find a treatment, an
exhaustive and impartial review is necessary in order to integrate the
knowledge that exists, to date, of the possible mechanisms through which
the treatment may be helpful in defining safe doses and schedules of
Ivermectin.
Filiaciones:
Inst Nacl Enfermedades Resp Ismael Cosio, Dept Epidemiol & Estadist, Mexico City 14080, DF, Mexico
Inst Nacl Pediat, Lab Farmacol, Mexico City 04530, DF, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio, Unidad Invest Farmacol, Mexico City 14080, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Mexico City 04510, DF, Mexico
Inst Nacl Med Genom, Lab Genom Metab Oseo, Mexico City 14610, DF, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio, Dept Invest Epidemiol Clin, Mexico City 14080, DF, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio, Lab HLA, Mexico City 14080, DF, Mexico
Fac Estudios Super Iztacala UNAM, Red MEDICI, Carrera Med Cirujano, Mexico City 54090, DF, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio, Dept Bioquim, Mexico City 14080, DF, Mexico
Inst Nacl Psiquiat Ramon Fuente Muniz, Subdirecc Invest Clin, Mexico City 14370, DF, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio, Dept Fibrosis Pulmonar, Lab Biol Mol, Mexico City 14080, DF, Mexico
gold, Green Published
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