Targeted Metabolomics Revealed a Sex-Dependent Signature for Metabolic Syndrome in the Mexican Population
Por:
Palacios-Gonzalez, Berenice, Leon-Reyes, Guadalupe, Rivera-Paredez, Berenice, Ibarra-Gonzalez, Isabel, Vela-Amieva, Marcela, Flores, Yvonne N., Canizales-Quinteros, Samuel, Salmeron, Jorge, Velazquez-Cruz, Rafael
Publicada:
1 sep 2022
Resumen:
Metabolic syndrome (MetS) is a group of several metabolic conditions
predisposing to chronic diseases. Individuals diagnosed with MetS are
physiologically heterogeneous, with significant sex-specific
differences. Therefore, we aimed to investigate the potential
sex-specific serum modifications of amino acids and acylcarnitines (ACs)
and their relationship with MetS in the Mexican population. This study
included 602 participants from the Health Workers Cohort Study. Forty
serum metabolites were analyzed using a targeted metabolomics approach.
Multivariate regression models were used to test associations of
clinical and biochemical parameters with metabolomic profiles. Our
findings showed a serum amino acid signature (citrulline and glycine)
and medium-chain ACs (AC14:1, AC10, and AC18:10H) associated with MetS.
Glycine and AC10 were specific metabolites representative of
discrimination according to sex-dependent MetS. In addition, we found
that glycine and short-chain ACs (AC2, AC3, and AC8:1) are associated
with age-dependent MetS. We also reported a significant correlation
between body fat and metabolites associated with sex-age-dependent MetS.
In conclusion, the metabolic profile varies by MetS status, and these
differences are sex-age-dependent in the Mexican population.
Filiaciones:
Med Fac UNAM INMEGEN, Sci Bonding Unit, Mexico City 14610, DF, Mexico
Natl Inst Genom Med INMEGEN, Genom Bone Metab Lab, Mexico City 14610, DF, Mexico
Natl Autonomous Univ Mexico UNAM, Res Ctr Policies Populat & Hlth, Sch Med, Mexico City 04510, DF, Mexico
IIB UNAM, Inst Biomed Res, Mexico City 04510, DF, Mexico
Natl Pediat Inst INP, Lab Inborn Errors Metab, Mexico City 04530, DF, Mexico
Morelos Mexican Inst Social Secur, Epidemiol & Hlth Serv Res Unit, Cuernavaca 62000, Morelos, Mexico
Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Hlth Policy & Management, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Fielding Sch Publ Hlth, UCLA Kaiser Permanente Ctr Hlth Equ, Los Angeles, CA 90095 USA
UCLA Ctr Canc Prevent & Control Res, Fielding Sch Publ Hlth, Los Angeles, CA 90095 USA
Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA
Natl Autonomous Univ Mexico UNAM, Fac Chem, Unit Genom Populat Appl Hlth, Mexico City 04510, DF, Mexico
Natl Inst Genom Med INMEGEN, Mexico City 14610, DF, Mexico
gold, Green Accepted
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