The Central Medial Thalamic Nucleus Facilitates Bilateral Movement Execution in Rats
Por:
Luma, Annie Y., Perez, Claudia I., Pimentel-Farfan, Ana K., Baez-Cordero, Ana S., Gonzalez-Pereyra, Perla, Ortega-Romero, Diana I., Martinez-Montalvo, Mario G., Pena-Rangel, Teresa M., Rueda-Orozco, Pavel E.
Publicada:
1 sep 2022
Categoría:
Neuroscience (miscellaneous)
Resumen:
Intralaminar thalamic nuclei, including the central medial nucleus
(CMT), have been classically implicated in the control of attentional
functional states such as sleep-wake transitions. In rodents, the CMT
innervates large cortical and subcortical areas bilaterally, including
sensorimotor regions of the cortex and striatum, but its contribution to
motor function, which regularly develops in faster temporal scales than
attentional states, is still far from being completely understood. Here,
by using a novel behavioral protocol to evaluate bilateral coordination
in rats, combined with electrophysiological recordings and optogenetic
manipulations, we studied the contribution of the CMT to motor control
and coordination. We found that optogenetic stimulation of the central
region of the CMT produced bilateral recruitment of neural activity in
the sensorimotor cortex and striatum. The same type of stimulations
produced a significant increase in bilateral movement coordination of
the forelimbs accompanied by a decrease in movement trajectory
variability. Optogenetic inactivation of the CMT did not affect motor
execution but significantly increased execution times, suggesting less
interest in the task. Altogether, our results indicate that brief CMT
activations create windows of synchronized bilateral cortico-striatal
activity, suit-able to facilitate motor coordination in temporal scales
relevant for motor execution. (C) 2022 IBRO. Published by Elsevier Ltd.
All rights reserved.
Filiaciones:
UNAM, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Campus Juriquilla,Blvd Juriquilla 3001, Queretaro 76230, Mexico
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